Loren Data Corp.

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COMMERCE BUSINESS DAILY ISSUE OF AUGUST 11,1998 PSA#2156

National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

67 -- VARIO -- SPEED SLOW SCAN CAMERA SYSTEM SOL RFQ80189-NS DUE 082498 POC Patricia Haun, 301-496-8613 The National Cancer Institute (NCI), on behalf of National Institute of Neurological Disorder and Stroke (NINDS), Laboratory of Neurobiology (LN), plans to procure a low-noise, scienitfic-grade, charge-coupled device (CCD) camera (Vario-Speed Slow Scan Camera System) from Leo Electron Microscopy Inc., 1 Zeiss Drive, Thornwood, NY 10594. The Laboratory of Neurobiology (LN) is responsible for investigating the fundamental cell biology of synaptic transmission, intracellular transport and the organization of specialized membranes in neurons. Important components of these studies concern calcium regulation of neuronal processes and the molecular organization of intracellular assemblies. Many of the principle techniques of modern structural biology, especially advanced electron microscopy and low-temperature preservation techniques, are essential tools in the Laboratory's research program. The LN's current instrument for this research is a LEO 912 Omega energy-filtering electron microscope, whose capabilities for low-dose, quantitative imaging, energy filtering, and cryoelectron microscopy would be greatly expanded by a sensitive CCD camera system. The CCD camera will be installed on and interfaced to the Leo 912 Omega energy-filtering electron microscope. The combination of these instruments will expand the capability and improve the convenience of recording data from rapidly frozen neuronal specimens, leading to an increase in research productivity. A slow-scan CCD camera system is required, and it shall be compatible to, installed on, and interfaced to the existing LEO 912 Omega energy-filtering electron microscope. The system shall include the following: 1) a Proscan Vario-Speed camera with 1Kx1K chip or equal; 2) independent, three stage peltier cooling and fiber-optic coupling for stable temperature and noise control; 3) digital controller with speeds of 2 Mhz at 14 bits and 5 Mhz at 8 bits; 4) microscope mounting flange and hardware (yielding minimal undesirable post-specimen magnification); 5)cooling device; 6) Windows/PC-based custom control software with compatible processing routines for the existing LEO 912 Omega electron microscope; 7) on-site installation and set up to meet the required performance; and 8) a one-year on-site parts and labor warranty. In addition, the camera system shall be optimized for low-dose imaging of beam sensitive biological specimens to provide a sensitivity of > 8 counts per incident electron. Furthermore, the noise level under low-illumination conditions shall be only one electron per readout or better. Leo Electron Microscopy, Inc., is the only source known to NINDS that can meet the above requirements and provide a camera system that is fully compatible with the mechanical, hardware, and software environment of the existing LEO 912 Omega electron microscope. However, if any interested party believes it can meet the above specifications, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing andmust contain material in sufficient detail to allow NCI/NINDS to determine if the party can perform the requirement. Capability Statements must be received in the contracting office by 3:00 p.m. EST, on August 24, 1998. If you have any questions, please contact Patricia Haun on (301) 402-4509. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Posted 08/07/98 (W-SN234333). (0219)

Loren Data Corp. http://www.ld.com (SYN# 0372 19980811\67-0002.SOL)


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