National Cancer Institute, Research Contracts Branch, PSAS, 6120 Executive Blvd, EPS/Room 638, Bethesda, MD 20892-7227

66 -- GENE CHIP EXPRESSION ANALYSIS SYSTEM SOL RFQ80049NR DUE 030298 POC Marsha Gorham, Purchasing Agent on (301)402-4509 or Trish Haun, CO The National Cancer Institutes plans to procure a Gene Chip Expression Analysis System and Analysis Software from Affymetrix Inc. 1145 Sonora CT, Sunnyvale, CA 94086. This is a combined sole source synopsis/solicitation for Commercial Items prepared in accordance with the format in the Federal Acquisition Regulation (FAR) 12.6, as supplemented additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation document and incorporated provisions and clauses are those in effect through FAR Circular 97-02. This acquisition is set-aside for small businesses. The Standard Industrial Classification Code is 5049 and the business size standard is 100. Affymetrix Inc. is the only source known to NCI that can meet the requirement and this notice of intent is not a request for competitive proposals. However, all responsible sources that believe that they can meet the requirement may submit offers. The Gene Chip Expression Analysis System will be used for the rapid detection of generic variation in DNA and RNA samples currently being collected. This system also will employ DNA chips produced to contain up to 25,000 DNA segments. This method is more sensitive and rapid than existing techniques. The system shall be capable of the following: 1. Shall combine solid phase chemical synthesis with photo lithographic fabrication techniques. 2. Shall be capable of scanning high density arrays of sequences which can be accessed simultaneously through automated con-focal argon laser interrogation. 3. Shall include image processing software capable of processing information from the high density arrays in 30 minutes or less. 4. The software shall be able to gather experimental information from the operator through dialog boxes. 5. The software shall be able to generate real-time image of fluorescence intensity information from the probe array and store it in a raw data file. 6. Shall have the capability to probe arrays withas many as 400,000 different probes. 7. Shall be able to scan a 1.28cm x 1.28cm probe array labeled with a single dye in 5 minutes. 8. The software shall automate the control of both the scanner and the fluidics station. 9. The software shall acquire and average hybridization intensity data as well as print image, sequence and report files. 10. The contractor shall provide a year 2000 warranty for each hardware, software, and firmware product delivered under this contract. The Contractor shall be able to accurately process date data (including, but not limited to, calculating, comparing, and sequencing) from, into, and between the twentieth and twenty-first centuries and the year 2000 and leap year calculations. Nothing in this warranty shall be construed to limit any rights or remedies the Government may otherwise have under this contract with respect to defects other than Year 2000 performance. The warranty shall otherwise be for a period of one year, parts and labor. Delivery shall be FOB Destination, inside delivery within 90 days after receipt of order. This solicitation incorporates the provisions at FAR 52.212-1, INSTRUCTIONS TO OFFERORS-COMMERCIAL ITEMS and at FAR 52.212-3, OFFER OR REPRESENTATIONS AND CERTIFICATIONS -- COMMERCIAL ITEMS. The latter provision includes the DUNS NUMBER ADDENDUM. The resulting contract will incorporate the requirements of the clause at FAR 52.212-4, CONTRACT TERMS AND CONDITIONS -- COMMERCIAL ITEMS, and the requirements contained in paragraphs (a) and (d) of the clause at FAR 52.212-5, CONTRACT TERMS AND CONDITIONS REQUIRED TO IMPLEMENT STATUES OR EXECUTIVE ORDERS COMMERCIAL ITEMS-DEVIATION FOR SIMPLIFIED ACQUISITIONS. The following FAR clauses cited in paragraphs (b) and (c) of the clause at FAR 52.212-5 are also applicable to this acquisition: FAR 52.222-26, "Equal Opportunity;" FAR 52.222-35 "Affirmative Action for Special Disabled and Vietnam Era Veterans; FAR 52.222-36 "Affirmative Action for Handicapped Workers;" FAR 52.222-27, "Employment Reports on Special Disabled Veterans and Veterans of Vietnam Era;" and FAR 52.225-3 "Buy American Act -- Supplies." All offers must be accompanied by a completed copy of FAR 52.212-3, OFFEROR REPRESENTATIONS AND CERTIFICATIONS -- COMMERCIAL ITEMS, with DUNS number addendum. These representations and certifications must be signed by an authorized representative of the offeror. Offers must be submitted on an SF-18 or SF- 1449 with a completed "Schedule of Supplies/Services." Offers must also be accompanied by descriptive literature, warranties, and/or other information that demonstrates that the offeror meets the foregoing requirements. The contract will be awarded to the lowest price offer that fully meets the requirements of the solicitation. All offers must be received within 20 days after publication of this notice, close of business (5:00 pm EST.). Full text copies of these representations and certifications or other cited provision and clauses may be obtained from Marsha Gorham, Purchasing Agent, on (301)402-4509 or by fax on (301) 402-4513. Please cite the solicitation number on your offer. (0040)

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