National Cancer Institute, Research Contracts Branch, PCCS, Executive Plaza South, Room 635, Bethesda, Md 20892

A -- EVALUATION OF CHEMOPREVENTIVE AGENTS BY IN VIVO SCREENING ASSAYS SOL MAA-N01-CN-75032-46 DUE 090797 POC Schuyler T. Eldridge, Contract Specialist, 301-435-3794 WEB: Research Contracts Branch RFP Page, http://wwwrcb.nci.nih.gov.gov/rfp.htm. E-MAIL: Schuyler T. Eldridge, se29f@nih.gov. The National Cancer Institute, Division of Cancer Prevention and Control, Chemoprevention Branch, wishes to award Master Agreement (MA) contracts for the above study. The required services will be defined by Master Agreement Orders (MAO) issued during the five year period of performance. This is a recompetition of the entire pool of Master Agreement Holders. All Master Agreement Holders must requalify to be eligible to compete for future Master Agreement Order (MAO) RFPs. Pursuant to the MAO the Contractor shall conduct in vivo screening studies in small rodents using gavage and other routes of administration to administer the designated chemopreventive agents in animal models using any carcinogenic mechanism (that is consistent with the Evaluation Criteria), such as the administration of carcinogens, promoters, hormones, irradiation, cells or other carcinogenic agents. Agents to be tested are potentially hazardous. The animal model systems also involve the use of carcinogens. Laboratory practices shall be employed which will keep any element of risk to personnel at an absolute minimum. Where indicated, tissue and compound handling must be performed in (at least) Class I laminar flow agents. It shall be required that the animal facilities be maintained in accordance with the NIH Guide for the Care and Use of Laboratory Animals, the Animal Welfare Act as administered by the USDA, and the U.S. Government Principals for Utilization and Care of Vertebrate Animals Used for Testing Research and Training. The contractor shall have all the equipment necessary to accomplish the studies including but not limited to animal racks and caging, hazardous chemical storage cabinets and refrigerators, pathology equipment such as microscopes and microtomes and miscellaneous laboratory equipment. The laboratory shall have or have access to appropriate terminal and computer facilities and equipment for data collection and storage. Since Master Agreements are unfunded the obligation of funds shall be accomplished solely throughthe award of Master Agreement Orders (MAO's). This research will be performed under cost reimbursement and/or fixed price MAO's. It is estimated that four (4) to five (5) Orders per year will be issued pursuant to the Master Agreement contracts. The Master Agreement Announcement is scheduled for electronic release on or about July 9, 1997. Proposal due date will be approximately September 9, 1997. The RFP may be accessed through the Research Contracts Branch RFP Page by using the following Internet address: http://wwwrcb.nci.nih.gov.gov/rfp.htm. It is the offerors responsibility to monitor the above Internet site for the release of this solicitation and amendments, if any. Potential offerors will be responsible for downloading their own copy of the solicitation and amendments. The Contract Specialist for this solicitation is Mr. Schuyler T. Eldridge Telephone: (301) 435-3794; Fax : (301) 402-8579; Contracting Officer is Mr. Victor S. Buyny. Collect calls will not be accepted. (0169)

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