Abt Associates Inc., 4800 Montgomery Lane, Suite 600, Bethesda, MD 20814

A -- HIV PREVENTION TRIAL SITES SOL NO1-AI-35176-JMEISTER2-97 DUE 040497 POC Contact Point, M. Levick, 301-913-0667 Abt Associates Inc. (Abt), under Contract No. NO1-AI-35176 with the Efficacy Trials Branch, Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, is soliciting proposals from organizations capable of participating in a multi-center seroincidence and preparatory study and subsequent clinical trials of vaccine and non-vaccine interventions for HIV prevention. Sites will be required to recruit a cohort of 200 to 800 volunteers for an initial seroepidemiologic study to document a rate of HIV seroincidence of at least 2 per 100 person-years and a minimum retention rate of 95% at 6 months. Subsequent studies may involve multi-center, randomized, controlled trials of preventive vaccine candidates, chemical (microbicides) and physical barriers to sexual transmission of HIV, behavioral interventions with HIV incidence as a primary outcome, and other innovative approaches to HIV prevention. It is anticipated that one to five cost-reimbursement, completiontype subcontracts for sites in addition to the current domestic HIVNET sites will be awarded for a period of five (5) years. The electronic version of SFP-NO1-AI-35176-JMEISTER2-97 will be available on or about February 3, 1997 through the NIH GOPHER, and may be accessed through the NIH Gopher and/or the Internet by using the following electronic mail addresses and instructions: 1) NIH Gopher: Point your Gopher client to GOPHER.NIH.GOV Port 70 (you should now be in the NIH Gopher); select "Grant and Research Information"; select "R&D Request for Proposals (RFP)"; select "RFPs Available"; select "NIAID"; and select "SFP-NO1-AI-35176-JMEISTER2-97". 2) Internet: The URL (Uniform Resource Locator) address is gopher://gopher.nih.gov:70/11/res/rd-rfp . All information required for submission of an offer will be posted on the NIH GOPHER. The anticipated deadline for responses to this SFP is April 4, 1997. Any responsible offeror may submit a proposal which will be considered by Abt and the Government. This notice does not commit the Government or Abt Associates Inc. to award a subcontract. Point of contact: HIVNET-DMC, (301) 913-0554. FAX (301) 718-3108; e-mail address: hivnet_dmc@abtassoc.com (0017)

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