SOURCES SOUGHT
A -- Dihexa Preparation and Supply, and Molecular Analysis Services
- Notice Date
- 7/10/2020 5:29:39 AM
- Notice Type
- Sources Sought
- NAICS
- 541715
— Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Contracting Office
- W4PZ USA MED RSCH ACQUIS ACT FORT DETRICK MD 21702-5014 USA
- ZIP Code
- 21702-5014
- Solicitation Number
- 20-P-0000-004996
- Response Due
- 7/14/2020 7:00:00 AM
- Archive Date
- 07/29/2020
- Point of Contact
- Kathleen Hamilton, Phone: 3016191078
- E-Mail Address
-
kathleen.e.hamilton4.mil@mail.mil
(kathleen.e.hamilton4.mil@mail.mil)
- Small Business Set-Aside
- SBA Total Small Business Set-Aside (FAR 19.5)
- Description
- This Request for Information (RFI)/Sources Sought (SS) Notice is for market research, information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of Madigan Army Medical Center (MAMC) or the US Army Medical Research Acquisition Activity (USAMRAA).� This market research is seeking Small Business sources only, that have the knowledge and capabilities to perform Dihexa Preparation and Supply, and Molecular Analysis Services on behalf of MAMC.� The objective of the proposed study Dihexa would enhance peripheral nerve regeneration and muscles innervation.�� The NAICS Code for this requirement is 541715 and PSC AN11 (NAICS Code 847714 and PSC code R699 will also be considered).��� Scope / Key Tasks:� -Procure, prepare and provide Dihexa and/or other relevant drugs, and assist in prepare hydrogel with Dihexa, as needed for the project. -Perform control experiments (Dihexa or G-CSF-untreated), using tissues obtained from normal animals, and study baseline for Dihexa target (HCF/c-Met) engagement and downstream targets including STAT3, STAT5, JAK2, ERK and AKT. -Study activated growth factor (HGF) receptor, total receptor expression and activated downstream targets in the skeletal muscle samples taken from distal (graft) and proximal (native) to limb transplant site, and spinal cord/nerve tissue samples. -Analyze relevant signaling molecules/transcription factors to study mechanistic action of Dihexa or G-CSF, and establish baseline levels in animals that do not receive Dihexa or G-CSF. -Conduct Dihexa and G-CSF target validation: perform immunoblot and immunochemistry analysis for Dihexa target (HGF/c-Met). -Study cell signaling mechanisms and/or transcription factors involved in the tissues of interest following Dihexa or G-CSF therapy. -Assists in the preparation of abstracts and manuscripts for presentations/publications, and progress reports for funding agency. The estimated period of performance would be TBD September 2020 � TBD September, 2023 (Base and Two (2) � 1 Year Options). No reimbursement will be made of any costs to provide information in response to this announcement or any follow up information requests.� Availability of any formal solicitation will be announced under a separate announcement.� This synopsis is for market research, information, and planning purposes only and is not to be construed as a commitment by the Government. Each response must reference the sources sought title. All proprietary information should be marked as such. Responses will be held confidential if requested. Please submit Fact Sheets/Capability Statements to: �kathleen.e.hamilton4.mil@mail.mil.
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/43a3eb88dd874459b303064a45e7eb39/view)
- Place of Performance
- Address: Joint Base Lewis McChord, WA 98431, USA
- Zip Code: 98431
- Country: USA
- Zip Code: 98431
- Record
- SN05718129-F 20200712/200710230201 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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