SOLICITATION NOTICE
Q -- Characterization of Human Arterial Immunoglobulin Repertoire (CHAIR)
- Notice Date
- 7/10/2020 11:15:51 AM
- Notice Type
- Presolicitation
- NAICS
- 621111
— Offices of Physicians (except Mental Health Specialists)
- Contracting Office
- NATIONAL INSTITUTES OF HEALTH NIDA Bethesda MD 20892 USA
- ZIP Code
- 20892
- Solicitation Number
- 75N95020Q00160
- Response Due
- 7/24/2020 9:00:00 AM
- Archive Date
- 08/08/2020
- Point of Contact
- Karen Mahon
- E-Mail Address
-
Karen.Mahon@nih.gov
(Karen.Mahon@nih.gov)
- Description
- PURSUANT TO FAR Subpart 5.2-Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT ACTION. THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Institute on Drug Abuse (NIDA), Office of Acquisition, Contracts Management Branch Blue, NIA Section on behalf of the National Institute on Aging intends to negotiate and award a purchase order to the Johns Hopkins University to perform the Characterization of Human Arterial Immunoglobulin Repertoire (CHAIR). North American Industry Classification Systems (NAICS) Code The intended procurement is classified under NAICS code 621111 with a Size Standard of $12 million. Regulatory Authority The resultant contract will include all applicable provisions and clauses of the Federal acquisition Requlation (FAR) in effect through the Federal Acquisition Circular (FAC) 2020-06, dated May 6, 2020. Statutory Authority This acquisition is conducted as non-competitive under the authority of 41 U.S.C. 253(c) under provisions of the statutory authority of FAR Subpart 6.302-1 -- Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements. This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source. Background and Objectives:� The goal of the Laboratory of Molecular Biology and Immunology (LMBI) is to elucidate molecular mechanisms of processes that contribute to age-associated changes in physiology, including diseases whose prevalence increases with age.�Our research has three interconnected themes: 1) molecular mechanisms of basic cellular processes, 2) immune cell function, and 3) translating basic mechanisms to clinical research. Major areas of emphasis include: 1) elucidation of molecular mechanisms that govern tissue-specific gene expression; 2) molecular mechanisms of antibody diversity, 3) mechanisms controlling T cell memory, and 4) contribution of regulatory immune cells to cancer. As described below for the individual programs, a wide variety of in vitro and in vivo models are employed to approach these issues. These processes have direct relevance to our understanding of critical events associated with various age-related deficits and/or development of age-related diseases including cancer.�LMBI investigators also study several aspects of human immunology.�These areas of research include: 1) functional changes in immune cell types that occur with age and their contribution to chronic inflammation; 2) properties of age-associated immune subsets and 3) the emergence of autoimmunity in the elderly. Project Requirements: The purpose of this requirement is for the Characterization of Human Arterial Immunoglobulin Repertoire (CHAIR), or more specifically to acquire arterial and peripheral B cells that will be analyzed to assess whether chronic inflammation during atherosclerosis drives the generation and activation of specific antibody clones. This acquisition is specifically for the isolation and collection of arterial tissue during surgery at Johns Hopkins Hospital. A cardiologist will be required to coordinate the acquisition of arterial tissue during vascular surgery performed at local hospitals. As a medical doctor, the cardiologist will have access to participants records to identify the ideal subjects. They will provide guidance on medically relevant and irrelevant data which is assist in the correct correlations being made between our immune cell findings and clinical disease. A vascular surgeon will be required to perform the tissue isolation. As the attending surgeon, they will present the research study to the participants, confirm that the meet the inclusion criteria, and coordinated with the NIA researchers when the surgeries will take place. During the procedure, they will isolate tissue relevant to the research study in conjunction with the NIA researcher present in the operating room, place the tissue in 1x PBS storage container, and provide peripheral blood to NIA researchers. Anticipated Period of Performance:� The anticipated period of performance is a 12 month base period and one 12 month option period. Closing Statement: This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this solicitation must include clear and convincing evidence of the offeror's capability of fulfilling the requirement as it relates to the technical evaluation criteria. The price quote must include the labor categories, an estimate of the number of hours required for each labor category, fully loaded fixed hourly rate or each labor category, breakdown and rationale for other direct costs or materials, and the total amount. The technical proposal must include CV information for proposed Key Personnel that meet the minimum requirements specified above. In addition, the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by Friday, July 24, 2020 at 12:00 PM Eastern Time and must reference number 75N95020Q00160. Responses must be submitted electronically to Karen Mahon at Karen.Mahon@nih.gov. Fax responses will not be accepted. ""All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.""
- Web Link
-
SAM.gov Permalink
(https://beta.sam.gov/opp/7211bd0025aa403c95140b2b2abad12c/view)
- Place of Performance
- Address: Baltimore, MD, USA
- Country: USA
- Country: USA
- Record
- SN05717498-F 20200712/200710230156 (samdaily.us)
- Source
-
SAM.gov Link to This Notice
(may not be valid after Archive Date)
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