MODIFICATION
66 -- Purchase of Cytation3 Cell imaging Multi-mode Microplate Reader or Equal Product
- Notice Date
- 9/18/2014
- Notice Type
- Modification/Amendment
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA-(SSSA)-14-748
- Archive Date
- 10/11/2014
- Point of Contact
- Andriani Buck, Phone: 3014021677
- E-Mail Address
-
andriani.buck@nih.gov
(andriani.buck@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- COMBINED SYNOPSIS / SOLICITATION This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in Subpart 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested and a written solicitation will not be issued. The solicitation number is HHS-NIH-NIDA-(SSSA)-14-748 and the solicitation is issued as a request for quotation (RFQ). This acquisition is for a commercial item or service and is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures; FAR Subpart 13.5-Test Program for Certain Commercial Items; and FAR Part 12-Acquisition of Commercial Items, and is not expected to exceed the simplified acquisition threshold. The solicitation documents and incorporated provisions and clauses are those in effect through Federal Acquisition Circular (FAC) 2005-76 effective August 25, 2014. This acquisition is unrestricted. The associated NAICS code 334516 and the small business size standard 500. STATEMENT OF OBJECTIVES The purpose of this requirement is to provide NTDU/NINDS with a high resolution multimode plate reader that can be used for microscopic imaging of neuronal cells in culture. The NTDU requires high speed and high content image acquisition and analysis cable of acquiring and analyzing hundreds of photomicrographs from neural stem cells and neurons which have been exposed to various chemical and/or biological toxins that represent or mimic neurodegenerative diseases. Equipment will be located in Building 49, room 5A67. Title: Purchase of Cytation3 Cell imaging Multi-mode Microplate Reader or Equal Product The National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency whose mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability, conducting, supporting and making medical discoveries that improve people's health and save lives. The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the National Institutes of Health (NIH), conducting research into the causes, treatment, and prevention of neurological disorders and stroke. The NINDS mission is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. The NINDS Neural Therapeutics Development Unit (NTDU) main research goal is to develop neurotherapeutic drug to treat neurological disorders. A high resolution multimode plate reader that can be used for microscopic imaging of neuronal cells in culture is needed. The NTDU plans to use this instrument for initial readouts of human neural stem cell and neuronal assays, followed up by high resolution imaging of these cells. NTDU requires high speed and high content image acquisition and analysis cable of acquiring and analyzing hundreds of photomicrographs from neural stem cells and neurons which have been exposed to various chemical and/or biological toxins that represent or mimic neurodegenerative diseases. These neurons will also be treated with potential therapeutic agents in an effort to block these neurotoxicities and to quantitate the neuroprotective potential of these agents. This data is a critical aspect of NTDU research into neurotherapeutic drug and new therapy development. The equipment must image a microplate, slide, petri plate, or T25 flask with up to four fluorescence colors and brightfield and read the plate for fluorescence, luminescence, absorbance, time resolved fluorescence, or fluorescence polarization and provide the ability to add reagents from dual reagent injectors and control the CO2 and O2 gases for live cell culture. All of these capabilities must be in one instrument box. Statement of Objective The purpose of this requirement is to provide NTDU/NINDS with a high resolution multimode plate reader that can be used for microscopic imaging of neuronal cells in culture. The NTDU requires high speed and high content image acquisition and analysis cable of acquiring and analyzing hundreds of photomicrographs from neural stem cells and neurons which have been exposed to various chemical and/or biological toxins that represent or mimic neurodegenerative diseases. Equipment will be located in Building 49, room 5A67. Scope of Work The contractor shall deliver and install the equipment meeting the requisite criteria. The equipment has to be during normal working hours (from 8:00 AM to 5:00 PM local prevailing time, Monday through Friday). Contractor shall provide the Biotek Instruments brand or equal Cytation3 Cell Imaging Multi-mode Microplate Reader, model CYT3MFV and accessories as outline below: 1.Biotek Model CYT3MFV Cytation3 Cell Imaging Multi-Mode Reader with monochromator and filter based multi-mode detection and automated imaging. Includes linear and orbital shaking, temperature control to 45°C. 2.Cat# 1220535 Firewire Laptop Card/supply set 3.Cat# 8040003S SVCE Dispense Box Dual 4.Cat# 1210008 Gas Controller for CO2 and O2 control. 5.Cat# SVCICT1 Basic Installation and Training Tier 2 6.Cat #1220519 Objective 4X with holder 7.Cat #1220518 Objective 10X with holder 8.Cat #1220517 Objective 20X with holder 9.Cat# 1225100 DAPI filter cube 10.Cat# 1225000 365 nm LED cube 11.Cat# 1225101 GFP filter cube 12.Cat# 1225001 465 nm LED cube 13.Cat# 1225102 Texas Red filter cube 14.Cat# 1225002 590 nm LED cube 15.Cat# 1225103 RFP filter cube 16.Cat# 1225003 523 nm LED cube 17.Cat# 8040502 Filter Block Asby Green/Red 18.Cat# 1220544 Objective 40X with holder 19.Cat# 1220545 Objective 60X with holder 20.Cat# GEN5IPlus Gen5 IPlus software V2.05.5 The instrument must be capable of the following: 1.Image a microplate, slide petri plate, or T25 flask with up to four fluorescence colors and brightfield and read the plate for fluorescence, luminescence, absorbance, time resolved fluorescence, or fluorescence polarization and provide the ability to add reagents from dual reagent injectors and control the CO2 and O2 gases for live cell culture. 2.Provide a true automated digital microscopy (fluorescence and brightfield) and multi-mode detection in one system. 3. Have capacity for multiple objectives. 4.Contain multiple microscopy color channels - four colors plus brightfield. 5.Have the ability to use 2.5x to 60x magnification to cover broad imaging applications 6.Contain a 16-bit CCD camera for dynamic range of >65,000 fluorescence units. 7.Be compatible with 6- to 384-well microplates, slides, Petri dishes and T25 cell culture flasks. 8.Have dual reagent injectors, able to automatically dispense reagents in all detection modes. 9.Have autofocus, autoexposure, auto-LED intensity adjustments 10.Have hybrid optical system combining a monochromator fluorescence optical system for flexibility with a filter-based fluorescence optical system for high performance in the same instrument 11.Contains quadruple grating optical design (two gratings per monochromator) for better spectral scanning performance. 12.Is capable of performing fluorescence, absorbance and luminescence spectral scans. 13.Is compatible with a gas controller for monitor and control of C02 (0%-20%) and 02 (1%-19%) levels to support live cell assays 14.Contains temperature control to 45 C with a 4-zone temperature control system, with uniformity across the microplate of ±0.5 C at 37 C to limit edge effects in incubated assays. 15.Is compatible with 2 µL low volume microplate accessory with 16- (Take3) or 48-sample (Take3TRIO) microspots for direct nucleic acid quantification as well as fluorescence and luminescence measurements. This plate can be purchased at any time after the instrument has been installed. 16.Includes image analysis software for automatic cell counting and sub-population analysis Delivery: Contractor shall deliver and install all equipment within 30 days after receipt of order. Warranty, Repair, and Maintenance resources: A two year warranty CONTRACTOR EXPERIENCE REQUIREMENTS - KEY PERSONNEL The contractor is expected to supply certified or trained personnel available to respond to a repair and maintenance issues onsite within 2-4 days Acceptance Final acceptance shall be upon the successful installation and operation of the above specified equipment. Please refer to the attached Statement of Work for further detail, specifications, and evaluation criteria. FAR clause 52.212-1, Instructions to Offerors - Commercial Items, applies to this acquisition. Offerors must include a completed copy of the provision at FAR clause 52.212-3, Offeror Representations and Certifications - Commercial Items, with its offer. FAR clause at 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition. FAR clause 52.212.-2, Evaluation - Commercial Items, is applicable to this requirement. Offers will be evaluated on (1) the capability of the system quoted and whether it meets the essential features as specified in the statement of work; (2) the government's desired delivery date of within 30 days after receipt of order; and (3) price. FAR clause at 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders-Commercial Items, applies to this acquisition. The Defense Priorities and Allocations System (DPAS) are not applicable to this requirement. Responses to this solicitation must include sufficient information to establish the interested parties' bona-fide capabilities of providing the product. The price quote shall include: unit price, list price, shipping and handling costs, delivery days after contract award, delivery terms, prompt payment discount terms, F.O.B. Point (Destination or Origin), product or catalog number(s); product description; and any other information or factors that may be considered in the award decision. In addition the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. All responses must be received by September 26, 2014, 8:00 am EST and must reference number HHS-NIH-NIDA-(SSSA)-14-748. Responses may be submitted electronically to andriani.buck@nih.gov or by U.S. mail to the National Institute of Drug Abuse (NIDA), Station Support / Simplified Acquisition Branch (SS/SA), 31 Center Drive, Building 31, Room 1B59, Bethesda, Maryland 20892-2080, Attention: Andriani Buck. Fax responses will be accepted at (301) 480-1358. Contact Andriani Buck at 301-402-1677 for information regarding the solicitation.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/HHS-NIH-NIDA-(SSSA)-14-748 /listing.html)
- Place of Performance
- Address: National Institutes of Health, Building 49, room 5A67, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN03518272-W 20140920/140918235837-79f5e23cf03ee1696051a0908845c3a3 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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