SOLICITATION NOTICE
R -- Biochemistry of Healthy Aging analysis of change from acetylation of proteins in tissue samples
- Notice Date
- 7/23/2014
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA(SSSA)-SBSS-14-489
- Archive Date
- 8/14/2014
- Point of Contact
- Hunter A. Tjugum, Phone: 301 435 8780, ,
- E-Mail Address
-
hunter.tjugum@nih.gov, NIDASSSAPurchaseRequ@mail.nih.gov
(hunter.tjugum@nih.gov, NIDASSSAPurchaseRequ@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- INTRODUCTION This is a Small Business Sources Sought (SBSS) notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This notice is issued to help determine the availability and type of qualified Small Business companies technically capable of meeting this potential government requirement and to determine the method of acquisition. It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract. Responses will not be considered as proposals or quotes. No award will be made as a result of this notice. The Government will NOT be responsible for any costs incurred by the respondents to this notice. The notice is strictly for research and information purposes only. The information requested will assist the Government in determining the appropriate acquisition method including small business socio-economic set-aside possibilities and to determine the availability of qualified Small Business companies technically capable of meeting the Government's potential requirement. All Small Business companies with the capability and availability to perform the requirement under the applicable NAICS code are invited to submit a response to this notice. NORTH AMERICAN CLASSIFICATION SYSTEM (NAICS) CODE The NAICS code applicable to this requirement is 541990 All Other Professional, Scientific and Technical Services with associated small business size standard $14.0 million. Background The National Institute on Aging (NIA), one of the 27 Institutes and Centers of NIH, leads a broad scientific effort to understand the nature of aging and to extend the healthy, active years of life. The Intramural Research Program (IRP) in the NIA consists of the Laboratory of Cardiovascular Science (LSC), which is driven by the following mission goals: (1) to identify age-associated changes that occur within the cardiovascular system and to determine the mechanisms for these changes; (2) to determine how aging of the heart and vasculature interacts with chronic disease states to enhance the risk for CV diseases in older persons; (3) to study basic mechanisms in excitation-contraction coupling in cardiac cells and how these are modulated by surface receptor signaling pathways; (4) to elucidate factors that maintain stem cell pluripotentiality, that promote the commitment of stem cells to the cardiac lineage, and that regulate their development as cardiac cells; (5) to elucidate mechanisms that govern cardiac and vascular cell survival; (6) to determine mechanisms that govern neuro-hormonal behavioral aspects of hypertension; and (7) to establish the potentials and limitations of new therapeutic approaches such as changes in lifestyle, novel pharmacologic agents or gene or stem cell transfer techniques in aging or cardiovascular disease states. In meeting these objectives, studies are performed in human volunteers, intact animals, isolated heart and vascular tissues, isolated cardiac and vascular cells, and subcellular organelles. The rate of aging is not fixed and can be modified in both positive and negative ways by environmental factors. The LCS is interested to elucidate certain key biochemical signals regulating healthy vs unhealthy aging, and this can be achieved, in part, by measuring certain covalent changes to a broad spectrum of cellular proteins. Purpose and Objectives The purpose of this small business sources sought notice is to determine eligible small business with the capability to provide all resources necessary to accomplish the tasks described in this notice. The LSC has a potential requirement for a contractor to compare the changes in acetylation of proteins in three different subcellular compartments (cytosol, nuclear and mitochondria) from a control group and up to 9 main treatment groups for the comparison. The goal is to identify the common overlap of the various treatment-related distributions of acetylated proteins. Three TMT 1 0-plex experiments will be required to compare 10 samples (control and 9 treatment groups) from 3 different subcellular compartments (cytosol, nuclear and mitochondria). A total of 30 samples will be analyzed. Making this comparison should enable the LSC to better understand how to promote healthy human aging through modification of certain key environmental variables. Project Requirements The essential government feature that this potential requirement needs to achieve is the ability perform and analyze mass spectrometry and peptides to compare the changes in acetylation of proteins in live tissue sample and delivery within 30 minutes of sample preparation. Deteriation of sample will result otherwise. Contractor must be able to access sample from the NIA government facility located at 251 Bayview Blvd, Baltimore, MD directly to the proteomics facility of the contractor for immediate proteomic analysis of that sample. The work specified in this announcement must be performed in a single proteomics facility. Capability statements sought Interested parties are expected to review this notice to familiarize itself with the requirements of this project. Failure to do so will be at your firm's own risk. Respondents must provide clear and convincing evidence of their capability to analyze tissue samples described in this announcement in a proteomics core facility equipped with full instrumental capability within the specified proximity necessary for achieving the efficiency and scale described in this announcement. Respondents must provide detail with how they will implement the sample analysis and other procedures needed to achieve the essential government features required for this potential requirement. Detailed past experience in implementing similar requirements to the requirement described in this announcement must be clearly delineated in any response provided, including items delivered and evidence of any published manuscripts or other documentation produced. Respondents must provide clear and convincing documentation of their capability in providing analytical quality control, reporting deliverables and any other supply or services related to this potential requirement. Respondents must provide a general overview of the respondents' opinions about the difficulty and /or feasibility of the potential requirement, and any information regarding innovative ideas or concepts. The Respondent must also provide information in sufficient detail of the respondents' (a) staff expertise, including their availability, experience, and formal and other training; (b) current in-house capability and capacity to perform the work; (c) prior completed projects of similar nature; (d) corporate experience and management capability; and (e) examples of prior completed Government contracts, references, and other related information. The respondent must also provide their DUNS number, organization name, address, point of contact, and size and type of business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements. All responses to this small business sources sought notice must reference solicitation number HHS-NIH-NIDA(SSSA)-SBSS-14-489 and be submitted electronically (via email) to Hunter Tjugum, Contract Specialist at hunter.tjugum@nih.gov and NIDASSSAPurchaseRequ@mail.nih.gov on or before the closing date specified in this announcement. Facsimile responses will be accepted at 301-480-1358. The response must not exceed 15 pages in total length in a Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2" x 11" paper size, with 1" top, bottom, left and right margins, and with single or double spacing. CONCLUDING STATEMENTS Disclaimer and Important Notes. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a pre-solicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. Confidentiality. No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).
- Web Link
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