SOLICITATION NOTICE
A -- Development and Maintenance of a Multigenotypic Aged Mouse Colony
- Notice Date
- 7/23/2014
- Notice Type
- Presolicitation
- NAICS
- 112990
— All Other Animal Production
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- HHS-NIH-NIDA(AG)-RFP-14-003
- Archive Date
- 8/22/2014
- Point of Contact
- Tawanda Haynes-Brown, Phone: 3014436162, Yvette Brown, Phone: 301-443-8402
- E-Mail Address
-
haynest@mail.nih.gov, yvette.brown@nih.gov
(haynest@mail.nih.gov, yvette.brown@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- PRESOLICITATION NOTICE The National Institute on Aging (NIA), National Institutes of Health (NIH), Department of Health and Human Services (DHHS) intends to re-compete a requirement currently being performed under NIA Contract HHSN271201000006I. This procurement is being competed under full and open competitive procedures under FAR Part 15. It is anticipated that a single Indefinite Delivery/Indefinite Quantity (IDIQ) type contract will be awarded on or about August 1, 2015 with a 10-year period of performance. It is expected that a solicitation will be issued on or about September 30, 2014. BACKGROUND: Current and projected experiments using rodents to model the aging processes and age-related diseases in humans require animals of defined genotype and controlled environmental and health status. Only with the meticulous, long-term control of genetic and environmental variables is it possible to maintain relevant animal models that may be used to study many of the biological and behavioral processes in aging. Therefore, a continuous supply of genetically defined, well characterized inbred and hybrid laboratory animals is essential for a program of research on aging. In 2010, NIA awarded a 9-year contract for the development and maintenance of a colony of genetically defined aged mice. This RFP contemplates award of a follow-on contract. PURPOSE AND OBJECTIVES: The purpose of this contract is to develop, maintain and distribute a standing colony of aged, genetically defined laboratory mice for use by investigators in studies of aging. This colony is to be developed and maintained within controlled and defined barrier environments where animals are monitored and characterized for disease status and markers of genetic purity. PROJECT REQUIRMENTS: The Contractor shall develop, maintain and distribute a standing colony of aged mice of NIA-specified genotypes for use by investigators in studies of aging. The expected duration of this colony, and therefore of this contract, is ten years. During years 1 through 2, animals shall be entered into the colony, but few animals shall be removed from the colony except for the purposes of monitoring health and genetic purity. However, if the need should arise, animals may be distributed from the colony at any time at the direction of the Contractor Officer's Representative (COR). During years 3 through 7, animals shall continue to be entered into the colony and animals shall be distributed to investigators. This should be a period of stable operation with young animals entering the colony at approximately the same rate as older animals leave the colony due to distribution and normal attrition. The final period, years 8-10, will serve as the colony close-out period. Animals shall be maintained and disbursed, but entry of animals shall cease at the beginning of year 8 or when entries begin in a renewal contract colony. Thus the population in this contract colony will decline to a point of zero or very few animals at the end of year ten. The colony population at the end of each year of the nine year period should be approximately as follows: YEAR 1 10,000 YEAR 4 72,000 YEAR 7 72,000 YEAR 10 Near Zero YEAR 2 50,000 YEAR 5 72,000 YEAR 8 50,000 YEAR 3 72,000 YEAR 6 72,000 YEAR 9 20,000 The Contractor shall acquire foundation stock for four inbred strains of mice from a stock center identified by the COR and shall re-derive the stock by caesarian section or embryo transfer under barrier conditions. After re-derivation, testing to confirm genetic purity and SPF health status shall be performed on the foundation colony, and breeding colonies will be established for the four inbred strains and two derivative hybrid strains. Mice will be entered into the aging colony at levels defined in the contract Statement of Work (SOW), currently a total of 4,150 mice per month (the hybrid strains account for approximately 5% of the total entry levels). The Contractor shall provide all production space needed for the colony, including at least two independent barriers to house the colony, with independent back-up and alarm systems. Since this is an aging colony, the contractor must be prepared to house the animals for up to 2-3 years each. Mice shall be provided with sterilized food (formulation consistent with NIH31 open formula) and bedding, and environmental conditions (temperature, humidity range, light cycle, water treatment, etc.) as defined in the SOW. Mice shall be monitored weekly for signs of fighting or morbidity. Semi-annual genetic monitoring of the breeding colonies and quarterly health monitoring of the aging colonies shall be performed and reported to the COR as well as be included in the semi-annual progress reports. Genetic monitoring shall be accomplished by a panel of microsatellite markers that distinguish the inbred strains. Health monitoring shall include external exams for parasites, microbiology, serology, and histology. The Contractor shall ship the mice to investigators upon authorization from the COR or her representative, providing secure shipping crates, food and water sources, climate-controlled transport and provide a weekly inventory of the aging colony in a format approved by the COR.. REPORTS/DELIVERABLES: The following reports will be required: (1) Post-re-derivation Health and Genetic Monitoring Report; (2) Breeding Colony Development Report; (3) Semi-Annual Progress Reports; (4) Weekly Inventory Report; (5) Health Monitoring Reports; (6) Genetic Monitoring Reports; Caloric Restricted Set-Aside Body Weight Reports; (7) Individual Postmortem Reports; and (8) Final Report. OTHER IMPORTANT INFORMATION: The North American Industry Classification System (NAICS) Code is 112990 with a size standard of $0.75 million. This proposed acquisition was previously publicized under sources sought notices HHS-NIH-NIDA(AG)-RDSS-14-003 and HHS-NIH-NIDA(AG)-SBSS-14-003. All responsible sources may submit a proposal which will be considered by the agency. This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/HHS-NIH-NIDA(AG)-RFP-14-003/listing.html)
- Record
- SN03434786-W 20140725/140723235256-cdad0f28224893ff5946471654814716 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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