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95 -- Silver Nanoparticles

Notice Date
Notice Type
Sources Sought
541712 — Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
Contracting Office
Department of Commerce, National Institute of Standards and Technology (NIST), Acquisition Management Division, 100 Bureau Drive, Building 301, Room B129, Mail Stop 1640, Gaithersburg, Maryland, 20899-1640
ZIP Code
Solicitation Number
Archive Date
Point of Contact
Micole A. Cheatham, Phone: 3019758335, Cheryl Rice, Phone: 3019753696
E-Mail Address
micole.cheatham@nist.gov, cheryl.rice@nist.gov
(micole.cheatham@nist.gov, cheryl.rice@nist.gov)
Small Business Set-Aside
This is a SOURCES SOUGHT NOTICE THIS IS NOT A REQUEST FOR QUOTATIONS The Ceramics Division of the National Institute of Standards and Technology (NIST) is developing two silver nanoparticle reference material, of 10 nm diameter and 75 nm diameter. This reference material must be aligned with international demands and expectations for quality of reference materials for silver nanoparticle standards, such as the Organization of Economic Cooperation and Development (OECD) testing programme's Working Party on Manufactured Nanomaterials (WPMN). Producing high quality silver nanoparticles suitable for reference materials is a challenging task. The company must be able to provide a product that meets the following technical specifications. Product Specifications: • Products must be manufactured by a U.S. vendor that has routinely demonstrated manufacturing silver nanoparticles that meet or exceed requirements for the Organization for Economic Cooperation and Development (OECD) Working Party on Manufactured Nanomaterials (WPMN) common test materials for silver nanoparticles. • Product #1, Nominal 10 nm diameter, Product #2, Nominal 75 nm diameter, diameter measurements based primarily on silver core diameter by transmission electron microscopy (TEM). Particles should be spherical in shape. • 6 L of 10 nm, 6 L of 75 nm, at 1.0 mg / mL (within +/- 10%) total silver content; minimum of 6.00 g silver in total per diameter, 12.00 g silver total order. • The mean TEM diameter of the silver core of the "10nm" particles must fall within the range of 8.0 nm to 12.0 nm, and the mean TEM diameter of the silver core of the "75nm" particles must fall within the range of 70.0 nm to 80.0 nm. • Have a C.V. less than +/- 20% for 10nm, and +/- 20% for 75nm (where C.V. is defined as one standard deviation of the mean of all NPs sized by TEM divided by the mean size), based on N>1000 for entire batch, or N>200 per smaller batch. • Product should have a polyvinylpyrrolidone (PVP) capping agent. • Excess synthesis reagents should be removed (for example, reducing agents, unreduced metal salts, intermediate capping agents), such that the purity of the product meets or exceeds OECD common test material purities. • An additional PVP content of 4 wt% should be added to the suspension. PVP should be of an approximately 10 kDa molecular mass (MW). • Particle cores must contain all silver. If seed-mediated methods are to be used, only silver seeds may be used; no gold, other metal, polymer, or any other material may be used as seeds. • Precursor material selection and process engineering should provide endotoxin levels in the final product to be less than 2.5 endotoxin units (EU)/mL. • Provide "testing aliquots" from (each) batch, containing no less than 20 mL, shipped overnight to NIST for testing and verification that using NIST's equipment aliquots can be freeze-dried into a powder, then resuspended by adding 5 mL of deionized water and waiting 1 hour, and recover all material into a monodisperse suspension as originally provided as measured by reproducing the absorbance spectrum (UV-vis), dynamic light scattering (DLS) intensity-based size distribution, and atomic force microscopy (AFM). If signs of agglomeration are present, the formulation request may be subtly modified at this point before shipping (such as adding additional PVP). • The materials should be able to kept in the dark and refrigerated whenever stored. The materials may be exposed to normal laboratory light during normal production, processing, and handling. • Quality assurance on each product should be performed and provided, including: o TEM diameters, following NIST - Nanotechnology Characterization Laboratory (NCL) protocol number PCC-7, and performing TEM measurements within 24 hours of particle deposition onto substrates. (http://ncl.cancer.gov/working_assay-cascade.asp) No less than 1,000 nanoparticles should be sized, with number-based size distribution histograms provided in addition to no less than 10 representative TEM images of the nanoparticles used for sizing analysis. o DLS Z-average size and intensity-based size distribution, following NIST-NCL protocol PCC-1. o Total silver content measurement by chemical analysis, for example by inductively coupled plasma mass spectrometry (ICP-MS). o Endotoxin test results, following appropriate NIST-NCL protocols. Additionally, data provided should include calibration curves with several concentrations of endotoxin positive controls only, silver nanoparticle solutions only, and several concentrations of endotoxin positive controls added to silver nanoparticle solutions; this will assure there is no false-positive or false-negative results due to the nanoparticles potential interference in the assay. o Ultraviolet-visible spectroscopy absorbance spectra. o All quality assurance methods and materials should be provided with the data. • Packaging & Shipping: o The materials should be packaged in sterile containers and sealed. o All materials must be able to arrive "fresh." Specifically, all the materials for a given product must arrive at NIST no later than three weeks from the commencement of the first reduction of silver atoms in the first batch ("start" of synthesis). "Testing aliquots" should be sent by overnight delivery to NIST no later than 8 calendar days after the start of synthesis (received by NIST no later than 9 calendar days after the start of synthesis), in order for NIST to verify acceptable freeze-drying performance. o Shipment should include proof temperatures did not exceed 45 ᵒC, or drop below 2 ᵒC. Companies should include in their response their plans for achieving each of the following specifications. Please include the company's size classification in any response to this notice. Small businesses are defined under the associated NAICS code for this effort. All documents must be sent to Micole Cheatham, contract specialist, at the National Institute of Standards and Technology, Acquisition Management Division, 100 Bureau Drive, Mail Stop 1640, Gaithersburg, MD 20899-1640. Email address: micole.cheatham@nist.gov. Submission must be received not later than 5:00pm Eastern Time on February 17, 2012.
Web Link
FBO.gov Permalink
Place of Performance
Address: Gaithersburg, Maryland, 21216, United States
Zip Code: 21216
SN02669377-W 20120209/120207235323-41d29d840523cd1ca7574a6182c0c7d8 (fbodaily.com)
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