MODIFICATION
A -- Liver Tissue & Cell Distribution System
- Notice Date
- 12/2/2011
- Notice Type
- Modification/Amendment
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Library of Medicine, 6707 Democracy Blvd., Suite 105, Bethesda, Maryland, 20894, United States
- ZIP Code
- 20894
- Solicitation Number
- NIH-LM-2012-233
- Archive Date
- 1/5/2012
- Point of Contact
- Christine S. Biser, Phone: 3015949987
- E-Mail Address
-
ChristineBi@mail.nih.gov
(ChristineBi@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The mission of National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support research on many of the most serious diseases affecting public health. The institute supports much of the clinical research on the diseases of internal medicine and related subspecialty fields, as well as many basic science disciplines. Among these diseases are end-stage liver diseases. To understand the pathophysiology of these diseases, it is essential to provide researchers with access to liver tissue and cells from a variety of end-stage liver diseases, as well as normal livers. These specimens would not be available to researchers who work outside a liver transplant center. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) requires an organization to provide the infrastructure for procurement and distribution of liver tissues and cells from a variety of end-stage liver diseases and normal livers to basic scientific investigators. The requirement seeks to facilitate the distribution of discarded liver tissue to qualified investigators to stimulate research on liver diseases. Recipients of cells and tissue from diseased livers are primarily investigators whose projects have been vetted by the NIDDK grant process. Available supplies of isolated hepatocytes from normal liver currently dictate that these are provided only to investigators at the National Institutes of Health. The scope of the program is comprised of procuring, isolating, purifying, preserving and distributing donor liver tissue, as well as reporting on this process. Donor tissue shall include whole or sectioned human liver tissue that is normal or shows pathology from a variety of liver diseases. This tissue shall be processed into liver tissue blocks (frozen, paraffin embedded,), hepatocytes suitable for cellular and molecular studies, and other preparations. To facilitate progress in liver research, to respond to the need of the investigators and to assess the evolution of the services, the contractor shall obtain periodic input from the scientific community regarding the provision of other liver specimens, particularly non-parenchyma cells. The requirement shall consist of the following tasks: 1. Clinical tasks, focused primarily on procuring donor tissue in a clinical setting. Specifically, the requirement shall include obtaining informed consent of organ donors; building a synopsis of donor's medical history and laboratory data; collecting whole or partial livers; and delivering this to a biotech laboratory for further processing. 2. Technical tasks, focused primarily on the isolating, purifying, and preserving the liver tissue in a biotech laboratory setting. The primary objective for tissues prepared with cryopreservation or histology techniques is a preparation that clearly preserves characteristic structures and pathology. The primary objective for cells is to maintain a high rate of cell viability. 3. Order Management tasks, focusing primarily on distributing the tissue to basic investigators. The primary objective is to deliver specimens in excellent condition; process financial accounting information; and track the production process. The system shall receive user requests; review and prioritize requests; maintain a fee schedule; receive and process payments; and communicate with investigators via a website; and support activities of a Coordinating Committee. 4. Reporting tasks, focusing primarily on collecting, analyzing and reporting data on the tasks described above. Specifically, data shall be presented on demographics, metrics, quality control, cost information, inventories, transaction activity and benefits of the program, such as the citations of publications resulting from this service. These data shall be analyzed and presented in graphic form. The requirement includes the ability to customize data queries, export query results to spreadsheet applications and graphically summarize and print query results. This task shall support the Coordinating Committee's strategic decision-making by providing the following types of information: review of operating procedures, quality control procedures, tissue processing procedures, information storage and management procedures, and operating policies ensuring equitable access to contract services. A cost-reimbursement type contract using NAICS code 541712 - Research and Development in the Physical, Engineering and Life Sciences (except Biotechnology), is contemplated. NLM intends to award a contract consisting of a base award and four option years on or about July 29, 2012. FAR Part 15 procedures will be used to compete this procurement with full and open competition. It is anticipated that the Request for Proposals will be released on or about December 21, 2011 at the FedBizOpps website. Contracting Office Address: 2 Democracy Plaza, Suite 700W 6707 Democracy Blvd., MSC 5455 Bethesda, MD 20892-5455
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/OAM/NIH-LM-2012-233/listing.html)
- Place of Performance
- Address: Contract performance location is not crucial., United States
- Record
- SN02632847-W 20111204/111202234532-53db734f62562c1d38560abe5892cd6c (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |