MODIFICATION
Q -- 3.0 TESLA MAGNETIC RESONANCE IMAGING -MRI
- Notice Date
- 10/17/2011
- Notice Type
- Modification/Amendment
- NAICS
- 333911
— Pump and Pumping Equipment Manufacturing
- Contracting Office
- NASA/Lyndon B. Johnson Space Center, Houston Texas, 77058-3696, Mail Code: BH
- ZIP Code
- 00000
- Solicitation Number
- NNJ12ZBH001L
- Response Due
- 11/1/2011
- Archive Date
- 10/17/2012
- Point of Contact
- Cheryl D. Bass, Contract Specialist, Phone 281-483-3476, Fax 281-483-7890, Email cheryl.d.bass@nasa.gov - LaToy J. Jones, Contracting Officer, Phone 281-244-8023, Fax 281-483-4066, Email latoy.j.jones@nasa.gov
- E-Mail Address
-
Cheryl D. Bass
(cheryl.d.bass@nasa.gov)
- Small Business Set-Aside
- N/A
- Description
- This is Amendment #2 to the synopsis entitled 3.0 Tesla Magnetic Resonance Imaging- MRI, NNJ12ZBH001L, which was posted on October 5, 2011. You are notified that theAmendment #2 supersede and replace the original Request for Information (RFI) in itsentirety with the following:This notice is issued by the NASA/JSC to post a Request for Information on Techniques forusing 3.0 Tesla Magnetic Resonance Imaging (MRI) to assess trabecular and cortical bonemineral density at central sties via the internet, and solicit responses from interestedparties. Request for Information (RFI): It is well established that bone mineral density (BMD)loss is rapid (1-1.5%/mo) and site-specific (axial and load-bearing sites) during longduration spaceflight. This loss occurs faster in the trabecular compartment than in thecortical compartment. A decreased BMD can be accompanied by other changes in bonestructure which increase the risk for bone fracture and early onset osteoporosis. Bonefracture could have serious implications for a long duration mission. Moreover, the riskfor early onset osteoporosis could limit the astronauts quality of life and careerlength. The current techniques used to evaluate BMD are Dual-energy X-ray Absorptiometry (DXA)and Quantitative Computed Tomography (QCT). BMD has the advantage of abundantepidemiological studies completed with its use, but it only provides integral (combinedcortical and trabecular bone); whereas BMDs of the separate compartments are importantfor understanding changes in bone structure vs. the remodeling of bone tissue. QCT hasbeen valuable and informative when used to measure BMD of the two compartments in the hipand spine, but it is a research technology for which clinical implications have yet to beestablished. Both DXA and QCT use ionizing radiation, which is undesirable since astronauts arescanned repeatedly to assess changes over time. It is important to minimize this exposureas can be reasonably achieved. Astronauts are already exposed to higher than normallevels of radiation during spaceflight. Therefore, DXA and other X-ray based technologiesare not optimal for quantifying the changes in trabecular and cortical bone mineraldensity. The astronaut population is currently being evaluated with 3.0 Tesla MRI scans forclinical monitoring and ongoing research protocols. NASA is interested in learning ifthere are techniques in development that could use MR technology to understand changes inbone mass and bone structure. The advantages of this modality are the resolution, lack ofionizing radiation, and decrease in astronaut crew time by having all studies performedat a single site. This Request for Information: 1. Is there a non-invasive technique that can utilize standard 3.0 Tesla clinicalMagnetic Resonance instruments to assess changes in bone mass in the trabecular andcortical sub-regions of bone similar to x-ray based modalities? We are most interestedin a technique for clinically-relevant sites of the central skeleton (proximal femur,femoral neck and spine). 2. If such a novel technique exists, how does the techniques reproducibility andaccuracy compare to measures by X-ray based modalities (DXA and QCT)? 3. What is the feasibility of adopting this novel MR-based technology? a. What are the risks associated with the technique? b. What are the initial cost and operational/maintenance cost?c. Are all the required components readily available or is specialized instrumentationrequired? d. What errors do you expect from spinal degenerative changes or aortic calcification? e. How does the technique correct for movement and water mass? 4. Can this technique provide information on bone morphometry? 5. Is this technique validated for making clinical decisions to improve outcomesregarding fracture risk and early onset osteoporosis (e.g. responsive to therapies,monitoring progression of pathologies)? 6. Are there other solutions with non-ionizing radiation (besides a possible 3.0 TeslaMRI) that could provide us this information? This document is for information and planning purposes and to allow industry theopportunity to verify reasonableness and feasibility of the requirement, as well aspromote competition. Prospective offerors are invited to submit written comments orquestions to: Cheryl Bass via e-mail, cheryl.d.bass@nasa.gov, no later than November 1,2011. When responding reference NNJ12ZBH001L - 3.0 Tesla MRI. Comments may be forwarded to Cheryl Bass via electronic transmission.This presolicitation synopsis is not to be construed as a commitment by the Government,nor will the Government pay for the information submitted in response. Respondents willnot be notified of the results.An ombudsman has been appointed -- See NASA Specific Note 'B'. The solicitation and any documents related to this procurement will be available over theInternet. These documents will reside on a World Wide Web (WWW) server, which may beaccessed using a WWW browser application. The Internet site, or URL, for the NASA/JSCBusiness Opportunities home page ishttp://prod.nais.nasa.gov/cgi-bin/eps/bizops.cgi?gr=D&pin=73 It is the offeror'sresponsibility to monitor the Internet cite for the release of the solicitation andamendments (if any). Potential offerors will be responsible for downloading their owncopy of the solicitation and amendments, if any. Any referenced notes may be viewed at the following URLs linked below.
- Web Link
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