MODIFICATION
R -- Genotyping Pathogenesis of HPE and Fatty Liver
- Notice Date
- 9/28/2011
- Notice Type
- Modification/Amendment
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-CSB-(HG)-2011-362-DLM
- Archive Date
- 10/14/2011
- Point of Contact
- Dorothy Maxwell, Phone: 301-435-0352
- E-Mail Address
-
maxwelld@mail.nih.gov
(maxwelld@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- THIS NOTICE OF INTENT WAS AMENDED TO CHANGE THE NAICS CODE, CHANGE HAS BEEN BOLDED. THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the National Human Genome Research Institute (NHGRI) intends to negotiate and award a purchase order on a noncompetitive sole source basis to University of North Carolina at Chapel Hill, 104 Airport Drive, Suite 220, Chapel Hill, North Carolina 27599-1350 to genotype genes involved in the pathogenesis of HPE and fatty liver. The sole source determination is based on the fact that National Institutes of Health (NIH) is the nation's leading medical research agency and the primary Federal agency conducting and supporting medical discoveries that improve people's health and save lives. NHGRI laboratory has discovered over ten genes associated with HPE and, in doing so, illuminated a number of key molecular processes involved in early embryonic development. NHGRI investigators have since identified a number of additional genes in the Sonic Hedgehog and Nodal signaling pathways that are implicated in HPE. Holoprosencephaly (HPE) is the most common malformation of the human forebrain. Affected individuals can have severe brain malformations and accompanying craniofacial anomalies, but mutation carriers may also be very subtly affected, with only slight facial differences and no other noticeable medical issues (this is often called "microform" HPE). Traditionally, nonsyndromic HPE (regardless of severity) has been thought to be an "above the neck diagnosis" in which only the brain and craniofacial features have any detectable anomalies. The overall objective is to further explore and determine the association between genes involved in the pathogenesis of HPE and fatty liver. The link between mutations in HPE-related genes and fatty liver through the use of a mouse model will be explored with the collaboration with the University of North Carolina at Chapel Hill. The University of North Carolina at Chapel Hill has a well-established mouse embryologist with extensive expertise in mouse models of HPE. The laboratory at the University of North Carolina-Chapel Hill has a long and impressive history of working with mouse models involving HPE-associated genes such as the ones our NIH lab studies. Critically, the North Carolina laboratory embryologist has already established mouse null lines for the HPE-associated genes that appear to be linked to fatty liver. These mouse lines are necessary for timely performance of research into the genetics of fatty liver in order to address our direct research questions. The North Carolina at Chapel Hill embryologist has extensive experience working with these models in the specific ways that our study requires. Due to preliminary work already established at North Carolina, collaborating with their University would significantly aid NHGRI in their studies, thus reducing time in the research due to the breakthrough that has already been accomplished at University of North Carolina at Chapel. Industry Classification (NAICS) Code is 541990, All Other Professiona, Scientific, and Technical Services, with size standard of $7.0M. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001).and the resultant purchase order will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-53 (August 4, 2011). This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis, by September 16, 2011, 7:30 a.m. Eastern Standard Time. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct future competitive procurement. Inquires to this announcement, referencing synopsis number NHLBI-CSB-(HG)-2011-362-DLM, may be submitted to the National Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6149, Bethesda, Maryland 20892-7902, Attention: Dorothy Maxwell. Response may be submitted electronically to maxwelld@mail.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. Note: In order to receive an award from the NHLBI, contractors must have a valid registration in the Central Contractor Registration (CCR) www.ccr.gov, and ORCA https://orca.bpn.gov/login.aspx.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-CSB-(HG)-2011-362-DLM/listing.html)
- Place of Performance
- Address: NIH, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02596444-W 20110930/110929000341-868fd0d4e7c35440e94dcda13db149df (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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