SOURCES SOUGHT
66 -- Ambient Desorption Ionization Source
- Notice Date
- 8/5/2011
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, Food and Drug Administration, Office of Acquisitions and Grants Services, Bldg 50 Room 422, Jefferson, Arkansas, 72079, United States
- ZIP Code
- 72079
- Solicitation Number
- 1090359B
- Archive Date
- 8/31/2011
- Point of Contact
- Marcia O Park, Phone: (870) 543-7405
- E-Mail Address
-
marcia.park@fda.hhs.gov
(marcia.park@fda.hhs.gov)
- Small Business Set-Aside
- N/A
- Description
- This notice is for Market Research purposes only, not a request for proposal or solicitation. The Food and Drug Administration (FDA) is seeking sources, including service-disabled veteran-owned small businesses, HUBzone small businesses, 8(a) certified small businesses, woman owned small businesses, small disadvantaged businesses as well as small businesses. The following information is provided to assist the FDA in conducting Market Research to identify potential contractors for providing the items below. The North American Industry Classification System (NAICS) code is 334516 - Analytical Laboratory Instrument Manufacturing with a small business size standard of 500 employees. The Food and Drug Administration/Office of Regulatory Affairs/Pacific Regional Laboratory-SouthWest requires an ambient desorption ionization source that will be used to analyze import produce samples for the presence of pesticide residues, active pharmaceutical ingredients (APIs) and chemical contaminants in foods and dietary supplements. An ambient desorption ionization source introduces chemical compounds into a mass spectrometer by desorption and ionization of an analyte. The ambient desorption ionization source can be used with a variety of mass spectrometer systems. This system will be used with an accurate-mass high resolution mass spectrometer. The mass spectrometer will be procured separately. However, the specifications for the mass spectrometer are provided for information to assist in determining compatibility of an ambient desorption ionization source that may be eventually proposed. Specifications for the ambient desorption ionization source to be used with the Mass Spectrometer are as follows: Salient Characteristics 1. The source must have a model available which can be interfaced with a mass spectrometer as described below 2. Ionized analytes must be produced by interaction of the analytes with excited-state species of inert gases. 3. The source must have an option to control the temperature of the inert gas with a maximum temperature of approximately 500 degrees Celsius 4. The source must have an option to allow a temperature gradient of the inert gas from ambient temperature up to maximum temperature of approximately 500 degrees 500 degrees Celsius 5. The source must be automated so that at least 5 samples may be run in one sequence 6. The source must have the capability to switch polarities when multiple samples are run 7. The source must have a linear rail that facilitates automated analysis of multiple samples in transmission mode (i.e., by passing the inert gas through the sample, which may be a material such as polyurethane foam or cotton gauze Mass Spectrometer Salient Characteristics (For information purposes only; not the subject of this market research effort) 1. A bench-top accurate mass spectrometer that can be interfaced with an ambient desorption ionization source. Due to limited laboratory space a bench-top system is required 2. The data system/instrument controller must be PC-based and include an operating system, instrument control/data acquisition/data analysis software, 19 inch flat screen color monitor, and laser printer. The data analysis software must include a structural elucidation component that allows for structural analysis based upon pattern recognition or other appropriate characteristics. 3. Additional ionization sources must be provided and they must be capable of supporting electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). Both ESI and APCI sources must be provided. 4. A syringe pump for infusion experiments must be supplied. 5. A diverter valve must be supplied for diverting solution flow to waste rather than to the mass spectrometer. 6. Any power line conditioner and/or uninterruptible power supply (UPS) necessary for proper operation of the mass spectrometer instrument must be provided. 7. The instrument must be capable of mass resolution of 100,000. High resolution (exact mass) is important for helping to identify known contaminants and previously unknown compounds (e.g., melamine-cyanuric acid complex) in complex food matrices which may contain isobaric interferences, especially if interferences are not resolved chromatographically. High resolution is very useful in deconvoluting overlapping ion signals in complex food matrices. 8. The instrument must be capable of mass accuracy <2 ppm with internal calibration. Mass resolution and mass accuracy are essential to accurately determine the identity of the analytes of concern. Mass accuracy of < 2 ppm is essential for determining elemental formulas of both known and previously unknown contaminants in complex food matrices. 9. The instrument must be capable of providing MS/MS ion fragmentation/spectra for structural elucidation. Fragmentation under multiple conditions, such as in-source (collision induced dissociation or CID) and in a quadrupole collision cell (higher energy collision induced dissociation or HCD), should be possible. MS/MS may be performed sequentially following acquisition of a high resolution scan. This allows more flexibility in structural elucidation of unknowns in complex sample matrices. 10. /the instrument must be able to support scan speeds of up to 10 scans per second when operating at a resolution of 10,000. Fast scan rates are critical when coupled with an ambient desorption ionization source, which is similar to infusion in the sample introduction process and the presence of the ions may be fleeting. 11. The instrument must have a minimum mass range of m/z 50-4000. 12. The instrument must provide signal-to-noise of greater than 10:1 for 500 fg of buspirone measured using the [M+H}+ ion at 386.2551 at a resolution of >50,000. 13. The instrument package shall include an N2 generator. 14. Installation of the instrument shall include the interfacing of an ambient desorption ionization source which will supplied separately (The subject of this market research effort) Potential contractors must indicate business size, proof of any set-aside certification and company's DUNS number and provide a contact name, the mailing address, phone number and email address of point of contact. Capability statement must provide enough information to determine if company can meet requirements stated above by including technical specifications, descriptive literature, brochures and other information that demonstrates the capabilities of the contractor to meet the requirements. Provide two contact names, email and phone numbers for user of the proposed system that may be contacted by the Government Responses are due in person, by postal mail or by email to the point of contact listed below on or before August 16, 2011 by 1:00 P.M. CDT at the Food and Drug Administration, OC/OA/OAGS, Attn: Marcia Park, 3900 NCTR Road, HFT-322, Jefferson, AR, 72079-9502. Reference 1090359B. Questions regarding this posting shall be submitted via email no later than 1:00 P.M. CDT on August 12, 2011. This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by the respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a solicitation may be published in the Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation. No proprietary, classified, confidential or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in a resultant solicitation that may result from this market survey. For information regarding this notice, contact Marcia Park, 870/543-7405, FAX 870543-7990 or email marcia.park@fda.hhs.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/FDA/NCTR/1090359B/listing.html)
- Place of Performance
- Address: 19701 Fairchild, Irvine, California, 92612, United States
- Zip Code: 92612
- Zip Code: 92612
- Record
- SN02524303-W 20110807/110805235548-f2cb64125ead46288aba8f1654c75c6e (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |