SOLICITATION NOTICE
R -- Professional Services Contract
- Notice Date
- 2/8/2011
- Notice Type
- Presolicitation
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-CSB-(DE)-2011-098-JML
- Archive Date
- 3/1/2011
- Point of Contact
- Jonathan M. Lear, Phone: 3014514470
- E-Mail Address
-
learj@nhlbi.nih.gov
(learj@nhlbi.nih.gov)
- Small Business Set-Aside
- Total Small Business
- Description
- THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisitions (OA), COAC Services Branch (CSB), on behalf of the National Institute of Dental and Craniofacial Research (NIDCR), intends to negotiate and award a purchase order on a noncompetitive sole source basis to Dr. Malini Ahuja, 728 Gatestone Street, Gaithersburg, MD 20878-2182 to provide Research Services in the Molecular Physiology and Therapeutics Branch (MPTB), NIDCR. The MPTB has a need for the services of an expert who can perform extensive mutagenesis of Ca²+ influx channels and produce mice that are defective in these channels. This expertise is necessary in order to expand upon the current studies in patients that are suffering from Sjogren's syndrome. Primary Sjogren's syndrome (SS) is a systemic autoimmune disorder characterized by exocrine gland dysfunction primarily involving the salivary and lacrimal gland. The histologic hallmark of SS is a periductal inflammatory infiltrate. The conventional explanation of salivary gland dysfunction assumes a causal relationship between this chronic inflammatory process and the decreased saliva production. However, most patients preserved salivary gland tissue, and overall, the correlation between the focus score on salivary gland biopsy (a measure of inflammation) and saliva production is limited. Recent studies at NIDCR have suggested that aberrant Ca²+ influx is critical for development of the disease and warrant further testing of the impact of the various Ca²+ influx channels of salivary glands to the disease state. In this study, NIDCR plans to understand the function and dysfunction of Ca²+ influx channels as they relate to Sjogren's syndrome and develop genetic and pharmacological tools to control channel function in vivo as a potential therapeutic approach to the disease. The specific tasks to be performed are to determine how regulation of the Ca²+ influx channels by the Ca²+ sensor STIM1 is altered in the disease and whether channel activity can be modulated safely to halt tissue damage. Mutagenesis screens and generation of mutant mice will be generated to approach the problem. The sole source justification is based on the fact that Dr. Malini Ahuja has the background, knowledge, and experience needed for the research of this project. Dr. Ahuja received her PhD in Biochemical Engineering and Biotechnology in 2001 and has four (4) years of experience in the field of molecular biology and physiology of Ca²+ channels, performing Ca²+ channel studies in muscle from mutant mice. Dr. Ahuja has an extensive background in both molecular biology techniques and analysis of Ca²+ channel function while working as a postdoctoral fellow and visiting scientist at the Johns Hopkins University, University of Maryland, and Duke University. Her experience and background are required for the needs of this research project. The period of performance will be from 03/01/11 - 02/28/13. The delivery point is the National Institutes of Health (NIH), National Institute of Dental and Craniofacial Research (NIDCR), Bethesda, MD. The North American Industry Classification System (NAICS) Code is 541711, Research and Development in Biotechnology, and is a small business set aside. The acquisition is being conducted under FAR Part 13, Simplified Acquisition Procedures, therefore the requirements of FAR Part 6, Competitive Requirements, are not applicable and the resultant purchase order will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2005-49 (January 24, 2011). Interested parties may identify their interest and capabilities in response to this synopsis by February 14, 2011 at 12:00pm Eastern Standard Time. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct future competitive procurements. Inquiries to this announcement, referencing synopsis number NHLBI-CSB-(DE)-2011-098-JML, may be submitted to the COAC Services Branch, Office of Acquisitions, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 6151, Bethesda, Maryland 20892-7902, Attention: Jonathan Lear. Responses may be submitted electronically to learj@nhlbi.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-CSB-(DE)-2011-098-JML/listing.html)
- Place of Performance
- Address: National Institutes of Health/NIDCR, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02375429-W 20110210/110209060237-a74a9ef92605857a49f7b005f6a196a1 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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