SOLICITATION NOTICE
B -- Perform CGH on Whole-Gonome Arrays
- Notice Date
- 9/8/2010
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- RFQ-NCI-100147-MM
- Archive Date
- 10/2/2010
- Point of Contact
- Melissa P Marino, Phone: 301-402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
marinome@mail.nih.gov, cr214i@nih.gov
(marinome@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute requires the following services. This is a combined synopsis/solicitation for commercial items, prepared in accordance with format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation: No. RFQ-NCI-100147-MM includes all applicable provisions and clauses in effect through FAR FAC 2005-43 (August, 2010) simplified procedures for commercial items. The North American Industry Classification Code is 541690 and the business size standard is $7.0M. Only one award will be made as a result of this solicitation. A. Project Objectives: The contractor shall perform CGH on whole-genome arrays (minimum density >700K) to identify copy number changes that are associated with disease in cancer-prone patients and/or cancer-prone families. Specifically, genomic DNA from blood samples of 280 subjects will be analyzed for arrayCGH to identify disease-related CNVs. Second, tumor and non-tumor DNA derived from formalin-fixed or alcohol-fixed paraffin embedded tissue from 500 subjects will also be analyzed for arrayCGH to identify CNVs associated with carcinogenesis. Findings from this study may help identify cancer gene variants in various types of cancer-prone patients or cancer-prone families and may provide new leads for understanding the causes of cancer in these different tumors, patients, and families. B.Contractor Requirements The vendor shall: 1. Label DNA samples and hybridize them to whole-genome arrays; 2. Include appropriate quality control step for the validity of the assay; 3. Scan arrays, extract and process data, perform segmentation analysis using the appropriate software; 4. Deliver raw and processed data (including visualization software); 5. Provide technical guidance and troubleshooting to the NCI Project Officer on the work performed under this procurement. C.Period of Performance: Performance shall be for twelve months from date of award. D.Government Responsibilities The NCI Contracting Officer's Technical Representative (COTR) will provide ungraded genomic DNA extracted from 280 blood samples and tumor-derived and non-tumor tissue DNA derived from formalin-fixed or alcohol-fixed paraffin embedded tissue from 500 samples required to complete the work. Government responsibilities for review and approval of reports and deliverables: Once the data are processed, the NCI COTR will review and approve them. E.Reporting Requirements and Deliverables Deliverables: Raw data Processed data Segmentation analysis file Genome annotation file Visualization software F.Inspection and Acceptance Requirements All data will be reviewed and approved by the COTR. The COTR will have 20 days in which to review and accept the submitted data. G.Clearances The NCI Clinical Center IRB or NCI Special Studies IRB approved the collection of blood samples and/or tumor samples from participants in the following studies included in this project (NCI IRB Protocol # 02-C-0211, 78-C-0039, 02-C-0210; NCI SS IRB Protocol #: OH95-C-N026, 02-C-N038, 02-C-N035, OH95-C-N027, OH99-C-N031). QUOTATIONS ARE DUE: September 17, 2010 at 11:00 am EST. PROVISIONS AND CLAUSES: The following FAR provisions and clauses apply to this acquisition: FAR clause 52.212-1 INSTRUCTIONS TO OFFERORS-COMMERCIAL ITEMS (June 2008); FAR clause 52.212-3 OFFEROR REPRESENTATIONS AND CERTIFICATIONS-COMMERCIAL ITEMS- (August 2009) WITH DUNS NUMBER ADDENDUM {52.204-6 (April 2008)}; FAR Clause 52.212-4 CONTRACT TERMS AND CONDITIONS - COMMERCIAL ITEMS (June 2010); FAR Clause 52.212-5: CONTRACT TERMS AND CONDITIONS REQUIRED TO IMPLEMENT STATUTES OR EXECUTIVE ORDERS-COMMERCIAL ITEMS (July 2010). The following FAR clauses cited in paragraph (b) of the clause at FAR 52.212-5 are also applicable to this acquisition; FAR Clause 52.203-6 Restrictions on Subcontractor Sales to the Government FAR Clause 52.219-4 Notice of Price Evaluation Preference for HUBZone Small Business Concerns. FAR Clause 52.219-8 Utilization of Small Business Concerns FAR Clause 52.222-3 Convict Labor FAR Clause 52.222-19 Child Labor-Cooperation with Authorities and Remedies FAR Clause 52.222-21 Prohibition of Segregated Facilities FAR Clause 52.222-26 Equal Opportunity FAR Clause 52.222-35 Equal Opportunity for Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans FAR Clause 52.222-36 Affirmative Action for Workers with Disabilities FAR Clause 52.222-37 Employment Reports of Special Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans FAR Clause 52.222-39 Notification of Employee Rights Concerning Payment of Union Dues or Fees FAR Clause 52.225-5 Trade Agreements FAR Clause 52.225-13 Restrictions on Certain Foreign Purchases Far Clause 52.232-33 Payment by Electronic Funds Transfer-Central Contractor Registration FAR Clause 52.247-64 Preference for Privately Owned U.S.-Flag Commercial Vessels Full text copies of the representations and certifications for other cited provisions and clauses may be obtained on line at the NCI website at http://amb.nci.nih.gov or from Melissa Marino, Contract Specialist at marinome@mail.nih.gov. OFFERORS: Offers must be submitted on an SF-1449 with a completed 52.212-3 Offeror Representations and Certifications-Commercial Items-with DUNS Number Addendum, signed by an authorized representative of the offeror OR provide a copy of the valid certification registrations of the offeror's Central Contractor Registration (CCR) and Online Representations and Certifications Applications (ORCA). PLEASE NOTE: In order to receive an award, contractor must be registered in and have valid certifications in the Central Contractor Registration (CCR) (http://www.ccr.gov) and the Online Representations and Certifications Application (ORCA) (http://orca.bpn.gov). Quotations must be received in the NCI-OA contracting office by 11:00 a.m. EST on September 17, 2010. Please refer to solicitation number RFQ-NCI-100147-MM on all correspondence. No collect calls will be accepted. Faxed or electronic mail quotations will NOT be accepted.
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