SOLICITATION NOTICE
66 -- High Resolution Mass Spectrometer
- Notice Date
- 8/3/2010
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Agriculture, Agricultural Research Service, Pacific West Area, WRRC, 800 Buchanan Street, Albany, California, 94710, United States
- ZIP Code
- 94710
- Solicitation Number
- HybridMS-PSM-2010
- Archive Date
- 9/1/2010
- Point of Contact
- Clarice E. Dixson, Phone: 510-559-6027
- E-Mail Address
-
clarice.dixson@ars.usda.gov
(clarice.dixson@ars.usda.gov)
- Small Business Set-Aside
- N/A
- Description
- The USDA, ARS, Western Regional Research Center, Albany, California has a requirement for a hybrid high resolution mass spectrometer (MS). This hybrid MS must consist of two functioning mass spectrometers; the first builds on linear ion trap technology, the second on an Orbitrap analyzer. The mass spectrometer must be able to perform parallel detection; within one minute of analysis time it must be capable of acquiring at least 50 full scans at high resolution (R=60,000 @m/z 400) detected with the Orbitrap detector AND in parallel 200 data dependant unit resolution MS/MS scan with the ion trap detector. The mass spectrometer must operate in the following mass ranges: 50 to 2,000 Da (Ion Trap and Orbitrap detection) 200 to 4,000 Da (Ion Trap and Orbitrap detection) 15 to 200 Da (Ion Trap detection). MS1 Quadrupole Ion Trap Mass Spectrometer Mass range • The mass spectrometer must operate in the following mass ranges: o m/z 100-4000 o m/z 50 - 2000 o m/z 15 - 200 Scan power • The mass spectrometer must be able to perform MS(exp n) experiments, for n = 1 through n = 10 MS/MS sensitivity (Specifications to be run at time of installation) • Must include heated electrospray ionization (HESI II) Must include atmospheric pressure chemical ionization (APCI) source MS(exp n) sensitivity • Heated Electrospray Ionization (HESI II) Transfer Ion Optics • Bent RF only square quadrupole to remove the line of sight from the source to the mass analyzer • The mass spectrometer must include both an RF only square quadrupole ion optic and an RF only octapole ion optic • The transfer ion optics must be designed for high stability and ion transmission efficiency Inter-Octapole Lens • The mass spectrometer must include an inter-pole lens orifice optimized for ion transmission from the square quadrupole to the octapole Quadrupole Ion Trap Mass Spectrometer • The analyzer must consist of a dual cell segmented linear ion trap • The analyzer must be constructed using hyperbolic surfaces • The analyzer must have parallel exit slits for radial ion ejection • The analyzer must have slots in X and Y rods to balance the RF fields • The analyzer dimensions must be optimized for ultimate performance • The mass spectrometer must have a simple rugged construction for ease of maintenance • The mass spectrometer must have a regulated helium flow for stable operation • The mass spectrometer must have automatic system calibration and optimization Detection System • The system must have two (2) detectors • The ions must be ejected radially from the ion trap • The detection system must have a patented, post-acceleration conversion dynode with ±15kV applied voltage • The detection system must have an off-axis continuous dynode electron multiplier with extended dynamic range, capable of detecting both positive and negative ions • The detection system must have digital electronic noise discrimination • The instrument must be capable of switching polarities within 100ms Data System • Minimum configuration must include o Intel® 3.2GHz Pentium® IV processor with 2 Gb memory, 160Gb hard drive, 3.5" 1.44Mb diskette drive, 16X DVD+RW/+R, Dell USB keyboard, Dell USB Optical mouse o 19" LCD flat panel color monitor o Integrated Intel Video Card o Integrated Ultra ATA100 controller card o PCI 10/100 Twisted Pair Ethernet network card o Operating system: Windows XP Professional o Microsoft® Office XP standard Scan Functions •Must acquire and display Full Scan MS/MS spectra to produce Full Scan product ion spectra at sensitivities higher than any quadrupole mass spectrometer at a speed of greater than 33,000 Da/s with unit resolution • Must acquire and display Selected Reaction Monitoring (SRM) data for a defined fragment transition • Must be capable of MS(exp n) multi-stage MS experiments to provide greater structural information • Must have an Enhanced Scan Mode capable of determining 3+ and 4+ charge state ions at 10,000 Da/s • Must have ZoomScanTM capability for high-resolution scan to resolve isotopic envelopes, of ions of at least 5+ charge state from 50-2000 Da at a scan speed of 2200 Da/sec • Must have TurboScanTM capability for ultra-fast scan to improve signal-to-noise and sampling rate of 125,0000 Da/s Advanced Functions • Must have Automatic Gain ControlTM (AGC) to automatically control ion injection time for optimized ion current across the entire chromatographic peak • When coupled with ETD the instrument must have Data dependent decision tree logic to determine the optimal fragmentation •Must have Dynamic ExclusionTM capability to temporarily exclude an ion while allowing acquisition of MS/MS or MS(exp n) spectra; increases the selectivity of co-eluting compounds, and enhances the signal of a selected compound MS 2 Orbitrap Mass Spectrometer Ion Transfer Optics • Must have a gas-free multipole ion transfer optics • Must have C-Trap as intermediate storage device Differentially Pumped Vacuum System • Must have multiple stages of differential pumping between C-trap and the Orbitrap • Must have a minimum of three turbo-molecular pumps • Must have rotary pumps as fore vacuum pumps • Pressure in the Orbitrap must be better than 1*10(exp -9) Torr Orbital Trap • Must have an electrostatic orbital trap • Must have very low electronic capacitance for high ion signal to noise Mass Resolution • 60,000 (FWHM) at m/z 400 at a spectrum repetition rate of 1 second • Must be able to obtain >100,000 resolution at m/z 400 in broadband mode Mass Accuracy • < 3 ppm RMS - with external standard using AGC • < 2 ppm RMS - with internal standard Dynamic Range • > 3*10(exp 3) within one spectrum (single transient acquisition) Scan Functions • as listed under MS-1 must be detectable (transient signal) with Orbitrap detector Advanced Functions • As listed under MS-1 CID Options • As listed under MS-1 HCD Options • Must have a straight multipole collision cell with axial field for Higher energy Collisional Dissociation MS(exp n) Performance • Scan speed for MSn, up to 3-4 MSn scans per sec at high resolution (R=15,000 at m/z 400) targeted or data depending decision triggered Maintenance • No cryogens needed for the FT-MS Upgrade options • The instrument must come equipped with ETD functionality on a chromatographic time scale. This solicitation incorporates the following commercial FAR clauses by reference 52.212-1, 52.212-2, 52.212-3, 52.212-4, and 52.212-5. Funds are not currently available for this acquisition and award will be made subject to the availability of funds. Interested vendors are encouraged to submit proposals containing descriptive literature (refer to FAR 52.214-21) of their products to Clarice Dixson, USDA, Agricultural Research Service, Western Regional Research Center, 800 Buchanan Street, Albany, CA 94710 or by e-mail to Clarice.Dixson@ars.usda.gov no later than 4:00PM PDST August 31, 2010.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/notices/cc0a5b4ff545874c36c3998aed210b61)
- Place of Performance
- Address: US Department of Agriculture, Agricultural Research Service, Western Regional Research Center, 800 Buchanan Street, Albany, California, 94710, United States
- Zip Code: 94710
- Zip Code: 94710
- Record
- SN02226607-W 20100805/100803235112-cc0a5b4ff545874c36c3998aed210b61 (fbodaily.com)
- Source
-
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