MODIFICATION
99 -- NLM2010065--Mass Spectrometer
- Notice Date
- 7/14/2010
- Notice Type
- Modification/Amendment
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- National Institutes of HealthNational Library of Medicine6707 Democracy BlvdSuite 700WBethesdaMD20892-7511
- ZIP Code
- 20892-7511
- Archive Date
- 8/12/2010
- Point of Contact
- Sonya Owens-Cobblah, Phone: 3015944666, Maxwell Kimpson, Phone: (301) 435-4380
- E-Mail Address
-
owenscobblahs@mail.nih.gov, kimpsonm@nlm.nih.gov
(owenscobblahs@mail.nih.gov, kimpsonm@nlm.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Institutes of Health (NIH), National Library of Medicine (NLM), intends to award a limited sources contract using the Justification for Limited Sources and Approval procedure to Thermo Electron North America LLC. This contract is for a mass spectrometer subsystem. This contract will include software integration, installation, testing, and maintenance. The institute intends to procure this service contract pursuant to FAR 8.405-6, Limited Sources Justification and Approval. Vendors may identify in writing their interest and capability in response to this requirement. This notice of intent is not a request for competitive proposals. However, all responses received before the closing date of this announcement will be considered by the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. All responsible sources may submit a quotation which, if timely received, shall be considered by the agency.This request is for interested firms with the capability of providing the items listed above and to submit a capability statement along with projected pricing, to assist the Government in determining in accordance with Federal Acquisition Regulation (FAR) 19.502-2(b) whether or not this procurement will be set-aside for any of the programs described above. The intended procurement will be classified under North American Industrial Classification (NAICS) code 334516/811219 with a size standard of 500 employees. Specifications: The LTD-velos-Orbitrap instrument was acquired in 2009 and is the NIDDK's current "most sensitive" mass spectrometer. Advances in the ion optics in the part of the instrument which first sees the electrospray plume and conveys selected ions into the high vacuum of the instrument make this instrument on the order of 20 times more sensitive than NIDDK's previous (and still operational) "most sensitive" instrument the LTQ-FTultra-ECD/IRMPD. Electron transfer dissociation is similar to electron capture dissociation in that they each involve delivering an electron into a highly charged molecule (although fragmentation will occur for +1 ions charge neutralization occurs for most interesting potential fragments and charge is required for measurement) where it rapidly leads to bond cleavage without any relaxation of the cleavage potential to other parts of the molecule. Such "non-ergodic" fragmentation can be useful in a wide range projects as it provides better sequence coverage than the more sensitive CID methods customarily used for fragmentation and the fragmentation is orthogonal-creating a different kind ion series which acts as an important filter for false positive identifications obtained through CID methods. ECD/ETD when coupled with the CID/HCD fragmentation methods available on the institutes' mass spectrometers is critical for any experimental stance which approaches a problem through a "de novo" approach whether this is done because the actual possibilities are not known or if such a stance reinforces the integrity of the experimental result. This important acquisition will allow us to apply slow electron based dissociation at approximately 20 times the sensitivity as we are able to apply it using the ECD in the detection cell of the FT-ICR mass spectrometer. In addition this upgrade provides improved redundancy in the facility with any one of the instruments potentially able to perform any desired experiment at the threshold created by less sensitive instrument. Through a historical effort to create matched fluidics and instrumentation the instruments could also be more effectively deployed on single extreme priority projects with great effect. POTENTIAL SOURCES SHALL PROVIDE THE FOLLOWING INFORMATION IN THEIR RESPONSE:Company name, address, phone number, primary contact(s), e-mail address, NAICS code(s), business size (i.e., small/large) and DUNS number.All respondents are requested to identify their firm's size and type of business. Interested firms responding to this market survey must provide (a) capability statement demonstrating their experience, skills and capability to fulfill the Government's requirements for the above. The capability statement shall be in sufficient enough detail, but not to exceed 10 pages, so that the Government can determine the experience and capability of your firm to provide the requirements above. Your capability statement, not to exceed 10 pages, should include references. A copy of the capability statement must be received at the address identified in this synopsis by no later than close of business (4:30 pm local time at designated location) on July 28, 2010 Responses by fax or e-mail WILL BE ACCEPTED. This announcement is for information and planning purposes and is not to be construed as a commitment by the Government, nor will the Government pay for information solicited. Vendors may identify in writing their interest and capability in response to this requirement or submit a proposal. This notice of intent is not a request for competitive proposals. However, all responses received before the closing date of this announcement will be considered by the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. All responsible sources may submit a quotation which, if timely received, shall be considered by the agency. The contract vehicle is a Firm Fixed price contract.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/notices/ba0d690980b4146c2a468f0292ea977c)
- Place of Performance
- Address: NIH-NIDDK, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02205770-W 20100716/100714235210-ba0d690980b4146c2a468f0292ea977c (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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