SOLICITATION NOTICE
B -- BREAST Stamp Project
- Notice Date
- 8/17/2009
- Notice Type
- Presolicitation
- NAICS
- 621512
— Diagnostic Imaging Centers
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90188-MM
- Archive Date
- 9/16/2009
- Point of Contact
- Melissa P Marino, Phone: 301-402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
marinome@mail.nih.gov, cr214i@nih.gov
(marinome@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), plans to procure on a sole source basis with California University San Francisco, 1855 Folsom Street, San Francisco, CA 94143 for services regarding the Breast Radiology Evaluation and Study of Tissues (BREAST) Stamp Project. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR Part 13.106-1(b)(1). The North American Industry Classification System Code is 621512 and the business size standard in $13.5M. Mammographic density is the strongest risk factor for sporadic breast cancer apart from age. Improving measurement of breast density and delineating its molecular epidemiologic and biologic characteristics may be useful for developing improved risk assessment and prevention strategies. Researchers in NCI / DCEG / HREB have conducted a successful pilot study to develop methods for an investigation to evaluate the molecular epidemiology and biology of mammographic density. Obtaining state-of-the-art density measurements was a central component of the pilot and is integral to the investigation. To meet this requirement, we have employed a novel technique for measuring breast density as a volume that was developed by Dr. John Shepherd at the University of California at San Francisco. The purpose of this requirement is twofold: 1) to perform analyses of images for 250 patients previously enrolled in the study and 2) to perform similar analyses of images for 200 newly recruited subjects for a total of 450 subjects in total. Therefore, for 250 subjects, we will assess volumetric breast density bilaterally as well provide area density measures and local density measurements around the biopsy target. In addition, for 450 women, we will assess density in 1) mirror image regions contralateral to the biopsy target to evaluate whether increased density at this comparable anatomic location is a marker of cancer precursors and cancer; 2) each breast quadrant to assess whether the elevated frequency of cancer in the upper outer quadrant is related to increased density and 3) the entire breast after excluding a specified volume beneath the nipple areola complex, thereby restricting density measures to peripheral breast tissue, the site where 99% of cancers arise. The University of California at San Francisco (UCSF) is the only source that is able to perform this work. UCSF developed the volumetric density methods, which includes designing and validating breast density phantoms, supporting hardware and software and related quality assurance programs. Pilot work using equipment already in the field has permitted successful data collection and Dr. Shepherd's laboratory has demonstrated the capacity to develop novel density metrics such as analysis of specific breast regions. These novel approaches will enable us to address important questions that remain unanswered in the literature related to the relationship of density surrounding a biopsy and lesion severity and variation of density within the breast. In addition, UCSF employs staff qualified to perform density volume measurements as well as breast density area measurements using validated techniques, allowing comparison of the two measurements. Finally, ongoing projects within the Breast Cancer Surveillance Consortium have already begun instituting the Shepherd method. Therefore, maintaining consistency within the Consortium will provide opportunities to pool data across sites. The same technique must be used as was used in the pilot and is used at other sites within the consortium to allow data pooling. Based on market research, the regional density measurements that NCI wishes to analyze have never been studied in the manner we propose. The proposed methodology was developed at UCSF and no market research was able to find a comparable technique that could accomplish all of the tasks required for this project This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the researcher to determine if the party can perform this requirement. An original and one copy of the capability statement must be received in the contracting office on or before 11:00 am ET on September 1, 2009 to Melissa Marino, Contract Specialist. All questions must be in writing and can be faxed to 301-402-4513 or sent via email to marinome@mail.nih.gov. It is the vendor's responsibility to ensure questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractors must be registered in and have valid certifications in the Central Contractor Registration (CCR), www.ccr.gov and the Online Representations and Certifications Application (ORCA) www.orca.bpn.gov. Please reference NCI-90188-MM on all correspondence.
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- Record
- SN01914463-W 20090819/090818001210-88b5af10d7be82baddefe34d1c860aa6 (fbodaily.com)
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