SOLICITATION NOTICE
68 -- 40 grams of the synthesis of deuterated trityl paramagnetic imaging contrast agent, OX071
- Notice Date
- 7/29/2009
- Notice Type
- Presolicitation
- NAICS
- 325188
— All Other Basic Inorganic Chemical Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- RFQ-NCI-90144-KM
- Archive Date
- 8/25/2009
- Point of Contact
- Karri L. Mares, Phone: 3014357774, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
maresk@mail.nih.gov, cr214i@nih.gov
(maresk@mail.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI) plans to procure 40 grams of the synthesis of deuterated trityl paramagnetic imaging contrast agent, OX071 This acquisition will be processed under FAR Part 12 – Acquisition for Commercial Items and will be made pursuant to the authority in FAR 13.106-1(b)(2) and 13.501-(a)(1) using simplified acquisition procedures for commercial acquisitions. The North American Industry Classification System Code is 325188 and the business size standard is 1000 employees. The Biophysics Branch in the Radiation Biology Branch at the National Cancer Institute is currently developing new imaging modalities to study physiological responses of tumors and normal tissues to radiation and chemotherapy drugs. The OX071 compound is a deuterated version of (tris[8-carboxy-2,2,6,6-tetrakis(2-hydroxymethol)benzol[1,2- d’ ]bix(1,3)dithio-4-yl]methyl radical) and is a contrast agent used in the NCI’s Electron Paramagnetic Resonance (EPR) imaging and low field Magnetic Resonance Imaging (MRI) studies. These imaging modalities rely on paramagnetic contrast reagents which exhibit a single narrow line EPR spectra, are water soluble, and are non-toxic in animals. OX071 is the most appropriate candidate that meets the above specifications. Contractor Requirements : Synthesis of the deauterated analog of the trityl radical [Oxo63; (tris[8-carboxy-2,2,6,6-tetrakis(2-hydroxymethol)benzol[1,2- d’ ]bix(1,3)dithio-4-yl]methyl radical)] deuterated at the methyl positions to confer longer spin-spin relaxation time and a consequent narrower EPR line width. The contractor shall provide the following compounds: 1) Oxo 71, the deuterated analog of the trityl radical [Oxo63; (tris[8-carboxy- 2,2,6,6-tetrakis(2-hydroxymethol)benzol[1,2- d’ ]bix(1,3)dithio-4-yl]methyl radical)] deuterated at the methyl positions in the quantity requested (40 grams). 2) The non-deuterated trityl radical Oxo 63; (tris[8-carboxy-2,2,6,6-tetrakis(2- hydroxymethol)benzol[1,2- d’ ]bix(1,3)dithio-4-yl]methyl radical) Quantity of 25 mg for spectroscopic comparison Only one award will be made as a result of this solicitation. Potential offerors may request a copy of the solicitation from Karri Mares, Contract Specialist via electronic mail at maresk@mail.nih.gov or fax (301) 402-4513. If you have questions regarding this notice, they may be addressed to the aforementioned individual noted above. When submitting your request please include complete mailing address, DUNS number, point of contact name, email, phone and fax number. Estimated issued date of the solicitation is August 10, 2009 with an estimated due date of August 24, 2009. No collect calls will be accepted. In order to receive an award, contractors must be registered and have valid certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Applications (ORCA). Reference: RFQ-NCI-90144-KM on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/RFQ-NCI-90144-KM/listing.html)
- Record
- SN01892550-W 20090731/090730002302-16642d1b1db49529e539719619a0b36e (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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