MODIFICATION
B -- Gene-environment interactions and risk factors for rare lymphoma subtypes and pooled analyses within the International Lymphoma Epidemiology Consortium (InterLymph)
- Notice Date
- 5/15/2009
- Notice Type
- Modification/Amendment
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90093-AV
- Archive Date
- 6/2/2009
- Point of Contact
- Ashley L. Virts,
- E-Mail Address
-
virtsa@mail.nih.gov
(virtsa@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Notice has been amended to correct period of performance. The correct period of performance is a base year plus one option period. The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Radiation Epidemiology Branch (REB) plans to procure on a sole source basis, Gene-environment interactions and risk factors for rare lymphoma subtypes and pooled analyses within the International Lymphoma Epidemiology Consortium (InterLymph) with Mayo Clinic College of Medicine, Department of Health Science Research, 200 First Street SW, Rochester, MN 55905-0002. The services herein are being procured in accordance with the simplified acquisition procedures authorized by FAR Part 13.106-(b) (1). The North American Industry Classification System Code is 541711 the business size standard is 500 employees. Period of Performance is twelve months from the date of award. The Radiation Epidemiology Branch (REB) within the National Cancer Institute (NCI) is currently conducting studies to understand the relationship between environmental and genetic factors and risk of NHL and its subtypes. Non-Hodgkin lymphoma (NHL) is composed of many closely-related, yet heterogeneous, diseases characterized by the malignant transformation of lymphoid cells but with distinctive morphologic, immunophenotypic, genetic, and clinical features. The strongest and most consistently observed risk factor for NHL is severe immunodeficiency, but the etiologies of most lymphomas remain unknown. InterLymph was formed in 2001 to undertake collaborative epidemiologic research to help discover the causes of NHL. Recent results from individual studies participating in the InterLymph Consortium have further suggested intriguing gene-environment interactions (e.g., autoimmune conditions, obesity, sun exposure, hepatitis C and atopy with TNF/IL 10 genotypes, and cigarette smoking with NAT1/2 phenotypes). However, none of the individually reported gene- environment interactions have sufficient power to robustly demonstrate such interactions statistically. In addition, data are lacking regarding potential specificity of the reported gene-environment interactions by NHL subtype. A unique opportunity therefore exists to examine pooled analyses within the International Lymphoma Epidemiology Consortium (InterLymph). The purpose of this procurement is to obtain the services of a contractor experienced in collaborating with InterLymph, as well as the conduct of pooled epidemiologic studies. Specifically, the contractor shall: (i) coordinate the request and receipt of key variables (e g., environmental and genetic factors, and lymphoma subtype definitions) from all participating InterLymph studies; (ii) harmonize key variables across all studies with detailed documentation regarding data cleaning and translation; and (iii) create pooled datasets for specific InterLymph analyses. In addition, because of the complexity of the consortial collaboration, the Data Coordinating Center at the Mayo Clinic has a history of effective, ethical and responsible collaborations with multiple institutions as well as high-quality computing, statistical and informatics resources including dedicated time of experienced data manager and analysts to standardize data and perform basic data analyses. Most importantly, the Mayo Clinic houses computing resources, server space, IT support and an encrypted contributor web-site for a data dictionary, documentation for variable creation, description of database software, specific statistical approaches and other key information needed to analyze the allotted information in the InterLymph study. Because the Mayo Clinic is the only Data Coordinating Center for InterLymph, it is essential that they perform the requested services. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the researcher to determine if the party can meet this requirement. One (1) original and one (1) copy of the capability statement must be received in the contracting office by 11:00 a.m. ET on May 18, 2009. All questions must be in writing and can be faxed to 301-402-4513 or sent via email to Ashley Virts: virtsa@mail.nih.gov. It is the vendor’s responsibility to ensure questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractor must have valid, updated registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Application (ORCA). Please reference NCI-90093-AV on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-90093-AV/listing.html)
- Record
- SN01820490-W 20090517/090516162342-e4e84e3fbffc0ff9930eb837b306e61c (fbodaily.com)
- Source
-
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