SOLICITATION NOTICE
B -- Specimen Preparation for Construction of Well-Annotated Progression and Prognostic Tissue Microarrays (TMAs) for Invasive Breast Carcinoma for Use in Breast Cancer Research
- Notice Date
- 9/5/2008
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-80226-MM
- Archive Date
- 10/7/2008
- Point of Contact
- Melissa P Marino,, Phone: 301-402-4509, Caren N Rasmussen,, Phone: (301) 402-4509
- E-Mail Address
-
marinome@mail.nih.gov, cr214i@nih.gov
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Division of Cancer Treatment and Diagnosis (DCTD), Cancer Diagnosis Program plans to procure on a sole source basis with Kaiser Permanente, Washington University School of Medicine, Fox Chase Cancer Center, and the University of Miami for Specimen Preparation for Construction of Well-Annotated Progression and Prognostic Tissue Microarrays (TMAs) for Invasive Breast Carcinoma for Use in Breast Cancer Research. The services herein are being procured in accordance with the simplified acquisition procedures authorized by FAR Part 13.106-1 (b) (1). The North American Industry Classification System Code is 541712 the business size standard is $7 M. The Cancer Diagnosis Program (CDP) has overall responsibility for planning, evaluation and coordination of NCI research and biospecimen resources related to cancer diagnostics. The Cooperative Breast Cancer Tissue Resource (CBCTR) was started in 1993 to provide breast cancer tissue specimens and accompanied long-term clinical follow up data to the breast cancer research community. It represents a model specimen biorepository which successfully supports a large variety of studies by a growing number of breast cancer investigators and is uniquely positioned to impact breast cancer research as well as the diagnosis, treatment and survival of thousands of breast cancer patients. The period of performance for this procurement will be 12 months from date of award. Contractor Requirements: The contractors must have access to a large number of well annotated invasive breast carcinoma pathology cases from a representative patient population from diverse geographic areas with 5-10 years of clinical follow data are needed for designing prognostic and progression TMAs with built in statistical significance. Clinical and outcome data fields associated with each case (patient) include: histological diagnosis, demographic data, extent of disease, treatment, follow-up, recurrence, survival and vital status. Each TMA requires several hundred breast cancer cases. Board certified pathologists need to select pathology blocks, cut slides from the blocks, perform QA/QC and identify of diagnostic areas of interest on the slides for coring and construction of the TMAs. QA/QC needs to be also performed to correlate statistical and clinical data used in the TMAs. Tissue specimens with well documented clinical follow up are required for the development and validation of diagnostic assays before they can be evaluated for their clinical utility in prospective clinical trials. The CBCTR is a collection of over 9,000 cases of archival breast cancer tissue with clinical and outcome data which is housed in four institutions: Washington University, St. Louis, MO; Fox Chase Cancer Center, Philadelphia, PA; University of Miami, FL and Kaiser Permanente, Portland, OR. It provides a critical and comprehensive collection of breast cancer tissue specimens and tissue miscoarrays (TMAs) for many academic and industry breast cancer researchers who are developing and validating biomarkers for prognosis and classification of breast cancer. No other readily available resource exists in the US that can provide access to such large numbers of specimens with high quality patient and outcome data developed using standardized data elements. Clinical and outcome data associated with each case (patient) include: histological diagnosis, demographic data, extent of disease, treatment, follow-up, recurrence, survival and vital status. Non-involved adjacent breast tissue is available for many of the cases. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the researcher to determine if the party can meet this requirement. One (1) original and one (1) copy of the capability statement must be received in the contracting office by 1:00 p.m. ET on September 22, 2008. All questions must be in writing and can be faxed to 301-402-4513 or sent via email to Melissa Marino: marinome@mail.nih.gov It is the vendor’s responsibility to ensure questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractor must have valid, updated registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Application (ORCA). Please reference NCI-80226-MM on all correspondence.
- Web Link
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- Record
- SN01661745-W 20080907/080905223442-fee0d31c314ce8c6c45c1ec5e8067ede (fbodaily.com)
- Source
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