Loren Data's SAM Daily™

FBO DAILY ISSUE OF AUGUST 15, 2008 FBO #2454
SOLICITATION NOTICE

B -- MOA of Nootkatone and Carvarol

Notice Date

8/13/2008
 

Notice Type

Combined Synopsis/Solicitation
 

NAICS

541380 — Testing Laboratories
 

Contracting Office

Department of Health and Human Services, Centers for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, Georgia, 30341-4146
 

ZIP Code

30341-4146
 

Solicitation Number

2008-59267
 

Response Due

8/28/2008
 

Archive Date

9/12/2008
 

Point of Contact

Maria S Shamburger, Phone: 770-488-2057
 

E-Mail Address

HEG9@cdc.gov
 

Small Business Set-Aside

N/A
 

Description

Document Type: Solicitation Solicitation Number: 2008-59267 Posted Date: August 13, 2008 Original Response Date: August 28, 2008 Current Response Date: August 28, 2008 Original Archive Date: August 28, 2008 Current Archive Date: August 28, 2008 Classification Code: B-Special Studies and Analysis-not R&D Set Aside: N/A Naics Code: 541380 Testing Laboratories Contracting Office Address Department of Health and Human Services, Center for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3708, Atlanta, GA, 30341-4146 Description The Centers for Disease Control and Prevention intends to issue a firm fixed priced purchase order. Naics code 541380 and size standard of $11 million in number of dollars applies to this order. The following items are needed by the Division of Vector-Borne Infectious Diseases. MOA Study, Quantity of 1 Year STATEMENT OF WORK (SOW) I. Background Arthropods transmit the etiologic agents of several human diseases causing an important impact on public health within the United States. The blacklegged tick, also known as the deer tick (Ixodes scapularis) is the principal vector of Lyme disease spirochetes, the agent causing human granulocytic ehrlichiosis, and human babesiosis. Fleas transmit plague causing bacteria in the United States, and mosquitoes transmit the West Nile Virus and other arboviruses within the United States. The primary means of controlling these arthropod vectors has mainly relied on the use of area-wide pesticides. However, the number of pesticides currently registered for arthropod control has been decreasing in recent years. Furthermore, many species have developed resistance to various classes of pesticides. Finally, many citizens are hesitant about the use of synthetic pesticides due to concerns about short range toxicity and long range health problems attributed to these chemicals. Plants have long been shown to have natural chemical defenses against arthropods. The exploitation of plants to provide natural, least-toxic pesticides and repellents is a high priority for CDC in the combat against vector-borne disease. In addition, DVBID scientists have been developing host-targeted methods of controlling disease vectors and reducing populations of infected rodent reservoirs. Development of new, environmentally safe vector-control methods is a very high priority for DVBID and CDC. Natural products may prove more acceptable to the public than traditional pesticides and have the potential to act against pesticide-resistant vectors. In addition, alternative natural based repellents with low to zero toxicity will benefit the public by providing an alternative to Deet and other synthetic repellents. Natural plant products as insecticides and repellents may provide an eco-friendly method of vector-borne disease control in the residential setting. This could be a win-win solution both for public health and the environment. CDC, DVBID scientists have researched, developed, and patented a class of all natural chemicals from botanical forest resources. The activity of these compounds has been intensely evaluated in both laboratory and field trials. The next step in the development and registration process of these compounds for public health use is to determine the mode of action (MOA) for these all natural compounds. II. Purpose Scientists at CDC/DVBID have patented a class of compounds extracted from Alaska yellow cedar (AYC). These compounds are comprised of both monoterpenes and eremophilane sesquiterpenes and are common to not only species of cedars but citrus products and other natural plants and herbs. Our research has revealed that these compounds are excellent candidates as acaricides, insecticides and repellents against important public health vectors including ticks, fleas, and mosquitoes. These compounds have been extensively evaluated in both laboratory and field trials with great success. We have evidence demonstrating the pesticidal and repellent activity of these compounds but now we need to determine how these compounds function to kill arthropods. Knowledge of the MOA will allow us to evaluate what class of synthetic compounds these natural products may potentially replace where insecticide resistance has become a problem. Determining the MOA might allow us to target resistant arthropod vector populations where pesticides with different modes of action have been heavily utilized. III. SCOPE OF WORK These will be initial attempts at determining the mechanism of action for two all natural compounds that have been researched, developed, and patented by CDC/DVBID scientists. We wish to have the MOA’s for carvacrol (a monoterpene) and nootkatone (an eremophilane sesquiterpene) evaluated. There are many registered/known pesticides that can be further broken down into common name/trade names, classes of pesticides, the targeted system or process of how they affect pests, and finally the mode of action. Therefore, we propose to the applicant to begin the process by targeting 5 primary MOA’s: 1) Cholinesterase Inhibition - Organophosphate and carbamate insecticides are known as cholinesterase inhibitors. They bind to the enzyme that is normally responsible for breaking down acetylcholine (Ach) after it has carried its message across the synapse. 2) Acetylcholine Receptor Stimulation - Neonicotinoid and spinosad insecticides act as agonists of the acetylcholine receptor. That is, they mimic the action of the neurotransmitter, ACh. 3) Chloride Channel Regulation – Avermectins, Organochlorine insecticides of the cyclodiene type and Bifenazate all have different derivatives but function as GABA receptor inhibitors, excitors, or agonists. 4) Sodium Channel Modulators - Pyrethrins and pyrethroids act on tiny channels through which sodium is pumped to cause excitation of neurons. They prevent the sodium channels from closing, resulting in continual nerve impulse transmission, tremors, and eventually, death. 5) Octopamine Receptor Agonists – Formamidines are thought to work by inhibition of the enzyme monoamine oxidase. This results in the accumulation of biogenic amines, e.g., octopamine. Formamidines induce abnormal behavior in pests: reduced feeding, dispersal from plants, erratic mating behavior, and detachment of ticks from their host. IV. TASKS TO BE PERFORMED The vendor shall perform the following tasks in the order shown: 1) Determine the MOA of nootkatone, a 15 carbon ring eremophilane sesquiterpene and carvacrol (isothymol), a 10 carbon ring monoterpene. The vendor will be provided with a minimum of 50 grams each of pure nootkatone (> 95%, nootkatone EX valencene) and carvacrol (> 85% isothymol). The vendor will determine the MOA of both natural compounds against an appropriate/suitable insect or arthropod species. The vendor can use appropriate in vitro, in vivo, and/or culture assays to determine the MOA. V. Government Furnished Property Not applicable. VI. PERIOD OF PERFORMANCE The period of performance shall commence upon receipt of a purchase order and shall continue for a period of 365 days. VII. Deliverables The vendor shall provide the following deliverables to the project officer by the dates shown: DELIVERABLESDATE REQUIRED A. MOA of nootkatone & carvarol Within 12 months after receipt of purchase against an appropriate insect ororder. arthropod species using in vitro, in vivo, and/or culture techniques. VIII. MINIMUM VENDOR QUALIFICATIONS The vendor must be fully familiar with the research areas of entomology, insecticide toxicology, environmental toxicology, and chemistry. The vendor should be proficient in the specifics of insecticide toxicology including mechanisms of action and toxicity. The vendor should have knowledge of natural products as insecticides. Interested persons may identify their interest and capability to respond to the requirement. Quotes will be due August 28, 2008 by 8:30 AM EST at the Centers for Disease Control and Prevention; Acquisition and Assistance Branch B; Attn: Maria Shamburger; 2920 Brandywine Road, Atlanta, GA 30341. An anticipated award date of August 29, 2008 is place. All responsible sources that can meet the above requirement may submit a quote, which will be considered by the Agency. All vendors need to be registered in the Central Contracting Registry (CCR) prior to award of a Federal contract. The preferred method for completing registration is via the World Wide Web at http://www.ccr.gov. A handbook and other information are available at the website, including information on how to obtain a DUNS number, which is required to begin the registration process. Point of Contact Maria Shamburger, Contract Specialist, Phone 770-488-2057, Fax 770-488-2044, Email heg9@cdc.gov
 

Web Link

FedBizOpps Complete View
(https://www.fbo.gov/?s=opportunity&mode=form&id=39094709addcc53dc5b777e0dd8a01d5&tab=core&_cview=1)
 

Place of Performance

Address: 2920 Brandywine Road, Atlanta, Georgia, 30341, United States

Zip Code: 30341
 

Record

SN01639253-W 20080815/080813223545-39094709addcc53dc5b777e0dd8a01d5 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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