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FBO DAILY ISSUE OF JULY 31, 2008 FBO #2439
SOLICITATION NOTICE

66 -- Laboratory Equipment and Installation

Notice Date

7/29/2008
 

Notice Type

Presolicitation
 

NAICS

334516 — Analytical Laboratory Instrument Manufacturing
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
 

ZIP Code

20892-7902
 

Solicitation Number

NHLBI-PB-AR-2008-195-RCO
 

Archive Date

8/27/2008
 

Point of Contact

Rosie C Owens,, Phone: (301) 435-7920, Kathleen Marsden,, Phone: 301.435.0364
 

E-Mail Address

rowens@mail.nih.gov, marsdenk@nhlbi.nih.gov
 

Small Business Set-Aside

N/A
 

Description

This is a combined synopsis/solicitation notice of intent for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NHLBI-PB (AR) 2008-195-RCO and is issued as a Notice of Intent (NOI). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-26. The North American Industry Classification (NAICS) Code is 334516 and the business size standard is 500. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. However, this solicitation is not set aside for small business. It is the intent of the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) for National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) to negotiate on a sole-source noncompetitive basis with Carl Zeiss MicroImaging, Inc., One Zeiss Drive, Thornwood, NY 10594, to procure an Upgrade to the existing Laser Dissection Microscope and service contract agreement. Upgrade MicroBeam C 355, MB03044 (415024001010000) to include laser and workstation, Installation of UV 355nm laser (UV355INSTAL) Image Analysis Celsius R650 Workstation (410203903000000), ATI Fire GL V5600 512 MB Grafic card (4103310600000000), Memory 2048 MB DDR2 RAM ECC (R640) (4103030201000000), Language Pack Win XP US (4103700200000000), Robo Software Update 3.2 (4151012600116000), Control Unit 7 (4151012400210), Video Cable DXC 390P Matrox (415105-3020-038). Research Focus: The requested upgraded PALM Laser System is essential and vital for the research study entitled: “Use of Bone Devired MSC and Chondrogenesis Invitro” Background: Musculoskeletal diseases such as arthritis constitute the major debilitating diseases in adult humans. To better understand the causes of this disease the research in my laboratory is centered on understanding the genetic basis of cartilage formation and homeostasis. Our goals are to identify genes that will aid in the formation of cartilage in cell culture and to use this newly formed cartilage in a tissue-engineering context to replace the worn out cartilage resulting from osteoarthritis. Towards this end we use adult human mesenchymal stem cells as a cellular source to form cartilage in cell culture. In concert with this process, we have begun to utilize a genetic engineering approach to modify existing cartilage proteins, such as the transcription factor Sox 9 and the extracellular matrix factor cartilage oligomeric matrix protein (COMP), so that we will be able to generate cartilage more efficiently in cell culture and that the cartilage formed will be better able to function when implanted into the body. Another ongoing project is to utilize genetic screens to identify genes that will help cartilage be more resistant to the factors that cause arthritis. These genetic screens have never been used to date in an orthopaedic or cartilage biology setting and therefore have enormous potential to aid in the discovery of new genes that will benefit halt the onset of osteoarthritis. Finally, we are setting out to explore the protective role of cartilage proteins in cancer. We are testing the hypothesis that certain cartilage proteins such as COMP limit the growth of cancer cells. In this way there may be an inverse relationship between arthritis and cancer such that the former may protect against the latter. Our initial investigations suggest that such a relationship may exist. Tuli R, Nandi S, Li WJ, Tuli S, Huang X, Manner PA, Laquerriere P, Noth U, Hall DJ, Tuan RS. Human Mesenchymal Progenitor Cell-Based Tissue Engineering of a Single-Unit Osteochondral Construct. Tissue Eng. 2004; 10(7): 1169-1179. Tuan RS, Eyre D, Schurman DJ. Biology of developmental and regenerative skeletogenesis. Clin Orthop. 2004; (427 Suppl): S105-17. Wang ML, Tuli R, Manner PA, Sharkey PF, Hall DJ, Tuan RS. Direct and indirect induction of apoptosis in human mesenchymal stem cells in response to titanium particles. J Orthop Res. 2003; 21(4):697-707. Rallapalli R, Strachan G, Tuan RS, Hall DJ. Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells. J Cell Biochem. 2003; 89(3):563-75 Noth U, Tuli R, Seghatoleslami R, Howard M, Shah A, Hall DJ, Hickok NJ, Tuan RS. Activation of p38 and Smads mediates BMP-2 effects on human trabecular bone-derived osteoblasts. Exp Cell Res. 2003; 291(1): 201-11. NIAMS owns a Zeiss PALM 1 laser micro-dissection catapult system which is 100% compatible with the Upgrade MicroBeam C 355. It is used for the manipulation of micro-dissection of living, frozen or paraffin-archived tissue for the collection of living cells, organelles, macromolecules (such as RNA) and biomaterials (i.e. particulates and wear debris). Zeiss is the manufacturer of two existing scientific instruments that provides micro-dissection of muscle and cell interaction analysis in the NIAMS’s laboratory; therefore, the upgrade must be 100% compatible. The upgrade system will allow the government to continue on-going projects such as tissue specific gene expression in would heal models during distraction posteogenesis and impact induced osteoarthrosis. The use of the Zeiss Laser is also merited given the extensive experience the lab has with the particular PALM laser. Furthermore, purchasing an upgrade model alleviates the cost of training associated with a different manufactures laser. The offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors Commercial; 2) FAR Clause 52.212-2, Evaluation Commercial Items. As stated in FAR Clause 52.212-2 (a), The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: Technical Evaluation and Price. 3) FAR Clause 52.212-3, Offeror Representations and Certifications Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions Required To Implement Statues or Executive Orders Commercial Items, Contract Terms and Conditions Commercial Items; and 5) FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items Deviation for Simplified Acquisitions. This action is under the authority of 41 U.S.C. 253(c) (1), as set forth in FAR 6.302-1 and HHSAR 306-302-1. Only one responsible source and no other supplies or services will satisfy agency requirement. Interested parties may identify their interest and capability to respond to the requirement or submit proposals. This notice of intent is not a request for competitive quotations however; all responses received within 15 days from the date of publication of this synopsis will be considered by the Government. A determination by the Government not to compete this proposed acquisition is based upon responses to this notice and is solely for the purpose of determining whether to conduct a competitive acquisition. The offeror must include in their quotation, the unit price, the list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. Note: In order to receive an award from the NHLBI contractors must have a valid registration in the Central Contractor Registration (CCR) www.ccr.gov. The clauses are available in full text at http://www.arnet.gov/far. Interested vendors capable of furnishing the government with the item specified in this synopsis should submit their quotation to the below address. Quotations will be due fifteen (15) calendar days from the publication date of this synopsis or by August 12, 2008, 5pm, Eastern Standard Time. The quotation must reference Solicitation number is NHLBI-PB (AR) 2008-195-RCO. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to the National Heart, Lung and Blood Institute 6701 Rockledge Blvd., Room Suite 6100, Bethesda, Maryland 20892, Attention: Ms. Rosie C. Owens, Contract Specialist. Responses may be submitted electrically to rowens@nhlbi.nih.gov or Ms. Kathleen Marsden, Contracting Officer, marsdenk@nhlbi.nih.gov and by fax 301-480-3345. Responses will only be accepted if dated and signed by an authorized company representative. Contracting Office Address: National Institutes of Health National Heart, Lung and Blood Institute 6701 Rockledge Blvd. Suite 6128, Bethesda MD 20892 Point of Contact(s): Attention: Ms. Rosie C. Owens, Contract Specialist or Ms. Kathleen Marsden, Contracting Officer
 

Web Link

FedBizOpps Complete View
(https://www.fbo.gov/?s=opportunity&mode=form&id=c4a82a61b3e8604fb89bd7ab2b3584a0&tab=core&_cview=1)
 

Place of Performance

Address: Bethesda, Maryland, Bethesda, Maryland, 20892-0001, United States

Zip Code: 20892-0001
 

Record

SN01625172-W 20080731/080729223019-c4a82a61b3e8604fb89bd7ab2b3584a0 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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