SOLICITATION NOTICE
66 -- Two AKTA Purifier UPC100 with FRAC 920 Liquid Chromatography Systems
- Notice Date
- 6/17/2008
- Notice Type
- Presolicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-80097-MM
- Archive Date
- 7/16/2008
- Point of Contact
- Melissa P Marino, Phone: 301-402-4509, Caren N Rasmussen,, Phone: (301) 402-4509
- E-Mail Address
-
marinome@mail.nih.gov, cr214i@nih.gov
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI) plans to procure on a sole source basis for two AKTA Purifier UPC100 with Frac 920 Liquid Chromatography Systems with GE Healthcare Bio-Sciences Corp., 800 Centennial Avenue, P.O. Box 1327, Piscataway, NJ 08855-1327. This acquisition will be processed in accordance with simplified acquisition procedures as stated in FAR 13.106-(b)(1) The North American Industry Classification System Code is 334516 and the business size standard is 500 employees. The following salient characteristics apply to the AKTA Purifier Liquid Chromatography Systems: •Ability to perform separations based on a variety of sample characteristics, such as molecular weight, net surface charge, hydrophobicity, while retaining biological activity •Flow rate change of.01-100 mls/min at pressures ranging from 0-10 MPa (1450 psi). Must include a motorized valve to enable reverse flow through a column so that elution may be carried out in the reverse direction or columns cleaned in the reverse direction to preserve column integrity. •two-pump gradient system, with dynamic mixing •Entire wetted flow path of the system must be inert to halides. The pump heads must be titanium with valves and tubing in PEEK. •system pumps should allow operation of the system at zero backpressure to ensure system compatibility with standard low-pressure chromatography supports. •Controller must allow programs to be time-based, volume-based, or column-volume based. •system should include the option of a fraction collector that is fully integrated into the system and fully controllable via the system control software. This fraction collector must have the capacity to fractionate into 175 x 12-mm diameter tubes or 95 x 10-18mm tubes. •System controller must allow the user to be entering details of the next purification at the same time the current separation is being done, or to simultaneously be integrating and evaluating the results of earlier runs. The software must allow complete manual control of all parameters and running conditions while running a method. •Pumps, UV, pH and conductivity monitors, valves and fraction collector must all be specified for use in a cold room at 4 degrees C. •The controller must accept seven input signals; must be capable of plotting, and integrating these signals, as well as using them to trigger sub-routines in the programming when the signal exceeds a preset threshold, to allow the automation of multi-dimensional separations. •Include on automatic three-position injection valve (load, inject, and wash positions), which allow for sample loading onto the column. •Column equilibration before and after sample injection and elution must be capable of being monitored, with a feed-back loop to the control system, so we can be certain equilibration is completed, without consuming excess volume of sometimes expensive buffers. •Documentation of each run should be automatic and exhaustive. Access to the controller must be by user name with password and level of access by each user must be definable by administrator. The software must be able to operate on the Windows XP operating system. •Post-run chromatographic analysis and reporting functions should also be included •definable pressure limit system defined when the column is selected from a list which will stop the pump and generate an audible and visual warning, in the event pressure exceeds the preset limit. •The controller must allow the user the option of including in his/her chromatographic methods programs, commands which will automatically reduce the flow rate if an over-pressurization occurs as sample is being applied or eluted from the column. Additional variables which should also be programmable to trigger sub-routines (e.g. new tube on fraction collector; valve changes; etc.) should include UV or conductivity signals. •should permit automatic running of up to 99 different chromatographic programs in a user-designated sequence. It must turn off the pump flow when a signal is received from the fraction collector indicating there are no tubes remaining, so that valuable sample is preserved. The system must automatically and continuously be able to record throughout each chromatographic run the following parameters: flow rate; UV signal; actual AND programmed conductivity of the eluent; eluent pH; system pressure; accumulated time of run; all valve positions and changes in position; activity of a fraction collector - and it must allow these recorded data to be called up later for interpretation and to aid in future replication of results. It must allow for post-run analysis of chromatograms, export of data to other spreadsheet programs, and generation of written reports JUSTIFICATION: 1.Statutory authority: Statute: 13.106-(b)(1) (b) Soliciting from a single source. (1)For purchases not exceeding the simplified acquisition threshold, contracting officers may solicit from one source if the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, or industrial mobilization). The GE Healthcare Bio-Sciences, formally Amersham Biosciences, AKTApurifer UPC 100 with FRAC-920 system is the only LC system which meets all of these requirements. GE Healthcare is the manufacturer and sole source supplier of the AKTApurifier UPC 100 system. This is the only source know to NCI which can meet these requirements. It is the only one of its kind and no other known supplier will be able to meet all of these needs. This is not a solicitation for competitive quotations. However, if any interested party believes they can meet the above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office by 1:00 PM ET on July 1, 2008. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Melissa Marino, Contract Specialist at marinome@mail.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference NCI-80097-MM on all correspondence.
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