SOLICITATION NOTICE
R -- Scientific Consulting
- Notice Date
- 8/14/2007
- Notice Type
- Solicitation Notice
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive Room 1B59, Bethesda, MD, 20892, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- NOI70098
- Response Due
- 8/29/2007
- Archive Date
- 9/13/2007
- Description
- This is a notice of intent, not a request for a proposal. A solicitation document will not be issued and proposals will not be requested. National Institute on Drug Abuse, Office of Acquisitions- Neurosciences, Station Support/Simplified Acquisition, on behalf of the National Institute of Mental Health (NIMH) intends to negotiate and award a purchase order on a noncompetitive basis to Johns Hopkins University School of Medicine, PDN is involved in a large phenomenological study focusing on the interrelationship between regression in autism and immune dysfunction. We propose to conduct a longitudinal natural history study of 50 children with autism and strictly defined regression, 50 children with autism and no history of regression, 50 typically developing children, and 25 children who meet criteria for Rett?s Disorder (a genetic disorder in which children have autistic features with clear regression). Subjects will be 12 ? 48 months of age at study entry in order to capture regression as close to its onset as possible. Systematic prospective evaluations will be utilized in order to provide validation to the phenomenon of regression in autism, determine diagnostic and functional outcomes, and evaluate behavioral, medical and immunologic functioning. 1. To characterize and validate the regressive phenotype in children with autism. 2. To characterize the immune response in children with autism. a. Distinct immunologic responses and cytokines abnormalities will be evident in children in the regressive autism sample, but not in the non-regressive autism, Rett?s Disorder, or typically developing samples. 3. To identify neurobiologic markers for autism through the techniques of metabolomics, proteomics and genomics (e.g. gene expression profiles). In addition, based on evidence of a pro-inflammatory profile seen in autism from the lab of Dr. Carlos Pardo, we have designed a treatment trial using the anti-inflammatory properties of minocycline. Efficacy will be tested by examining the cytokine and chemokine profiles of serum and cerebrospinal fliud (CSF) before and after treatment. The period of performance: 12 Months. The North American Industry Classification (NAICS) Code is 541690 and the Size Standard. An award to any other source would affect the NIH prior and current research. The acquisition is being conducted under simplified acquisition using FAR 13 procedures and is exempt from the requirements of FAR Part 6, Competition Requirement. This notice of intent is not a request for competitive proposals. Interested parties may identify their interest and capabilities in response to this synopsis. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely with the discretion of the Government. Comments to this announcement, referencing synopsis number NOI70098 may be submitted to the NIDA, Station Support/Simplified Acquisition Branch, 31 Center Drive, Bldg 31, Room 1B59, Bethesda, MD 20892-2080, and Attention: Kathleen Gregory, Contracting Specialist.
- Place of Performance
- Address: Bethesda, MD
- Zip Code: 20892
- Country: UNITED STATES
- Zip Code: 20892
- Record
- SN01371724-W 20070816/070814220507 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |