SOLICITATION NOTICE
B -- Effect of 10 Days of Bed Rest Followed by 60 Days of Rehab on Muscle and Adipose tissue in the Thigh of a Group of Older People
- Notice Date
- 7/19/2007
- Notice Type
- Solicitation Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD, 21224, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- LEDB0733
- Response Due
- 8/2/2007
- Archive Date
- 8/17/2007
- Description
- The National Institute on Aging, IRP, intends to negotiate and award a purchase order on a noncompetitive basis with the University of Arkansas for continuation of research to ascertain the effect of 10 days of bed rest followed by 60 days of rehab on muscle and adipose tissue in the thigh of a group of older people and how changes in these tissues correlate with changes in peripheral and central insulin resistance. It is well known that bed rest is associated with loss of muscle in younger persons and with persons put on bed rest for experimental purposes. Dr. William Evans and his group at the University of Arkansas Medical Sciences have demonstrated that there is almost double the loss of muscle tissue in older persons compared with younger persons on 10 days of bed rest. In these protocols, he is obtaining muscle tissue from biopsy and has shown an increase in muscle breakdown greater in older compared to younger persons. He is using dual energy x-ray absorptiometry to quantify muscle in these protocols. Use of computerized tomography in these experiments would allow extension of this work to examine the specific effect of bed rest on atrophy of particular muscle groups on change in intermuscular adipose, and on change in muscle attenuation, an indicator of the infiltration of adipose into muscle below the level of resolution needed to define aggregate adipose tissue. These effects can be correlated to the physiologic measurements already planned for this bed rest experiment, including measures of hepatic glucose uptake and hepatic insulin resistance as well as peripheral insulin resistance and protein synthesis. In addition, because each participant is being given a 60-day rehabilitation period, we can assess whether the structural changes secondary to bed rest are completely reversed. Only one responsible source and no other supplies or services will satisfy agency requirements, 41 U.S.C. 253 (c) (1), FAR 6.302-1(b) (1). The cited authority is applicable because the University of Arkansas is the only source that can fulfill the requirements of this contract. Dr. William Evans, Univ of Arkansas, is a world-renowned expert on body composition and metabolism in older people. He has an NIH-funded Program Project to explore acute changes in body composition in older persons through a series of bed rest studies that he initiated over a year ago. These are critical studies because they are tightly controller in terms of the physiologic challenge to metabolic homeostasis and are the gold-standard for acute change in body composition. However, because of the risks associated with this, they are rarely carried out in older persons. Dr. Evans work is strictly supervised by his IRB and he has provision for rehabilitation after the bed rest. Unfortunately, there is no imaging component to his project and this creates the opportunity to add investigation of unique and critical data to ongoing studies that could not be replicated. Thus, sole source is justified because of the scope of the work, the unique opportunity to add measurements to this work and the scientific opportunity this creates, and because of Dr. Evans? unparalleled expertise in this area of research. The period of performance is 12 months. The North American Industry Classification (NAICS) is 541990 and the size standard is $6.5 million. This acquisition is being conducted under Simplified Acquisition procedures and is exempt from the requirements of FAR, Part 6, Competition Requirement.
- Place of Performance
- Address: 5600 Nathan Shock Drive, Baltimore, MD
- Zip Code: 21224
- Country: UNITED STATES
- Zip Code: 21224
- Record
- SN01346659-W 20070721/070720001041 (fbodaily.com)
- Source
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