SOLICITATION NOTICE
66 -- C13 Hypersense DNP Polarizer
- Notice Date
- 6/11/2007
- Notice Type
- Solicitation Notice
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852, UNITED STATES
- ZIP Code
- 00000
- Solicitation Number
- Reference-Number-NCI-70066-NG
- Response Due
- 6/21/2007
- Archive Date
- 7/6/2007
- Description
- The National Cancer Institute (NCI) plans to procure on a sole source basis the purchase of a C13 Hypersense DNP Polariser which includes the HyperSense installation/starter pack and solid state detector; with Oxford Instrument America, Inc; 300 Baker Avenue, Suite 150; Concord, MA 01742. This acquisition will be conducted under the procedures for acquiring commercial items authorized in FAR Part 12 and under the authority to use simplified procedures for commercial requirements as provided in FAR 13.501. The North American Industry Classification System code is 334516 and the business size standard is 500 employees. The salient characteristics apply to the C13 Hypersense DNP Polariser and inclusions: Dimensions: Height 2860 mm or 113 inches; Width 1668 mm or 66 inches; Depth 1038mm or 41 inches. C13 Hypersense DNP Polarizer: - low temperature (<3.4 K) polarizer using the Trityl radical for use in animals and humans; - interaction under extremely low temperatures (1.4 - 3.4 K) of the dynamic polarization transfer from the electron to 13C or 14N labeled compounds; - unpaired electron (in the Trityl radical) must be polarized using a 94 GHz microwave source and temperatures < 3.4◦ K must be maintained to achieve optimal spin polarization transfer. - 94 GHz microwave source with 0.5 GHz sweep and a power output up to 180 mW; - 3.35 Tesala actively shielded magnet operating at 4.2 Kelvin; - able to set polarizer sample temperature to < 3.9 Kelvin and 1.4 Kelvin at 180 mW; - helium consumption during dissolution must be < 2 Liter per dissolution Justification: The NCI is developing new imaging modalities to study physiological responses of tumors and normal tissues to radiation and chemotherapy drugs. The HyperSense DNP Polariser is a means of detecting C13 labeled compounds using MRI pulse sequences. Using C13-labeled pryuvate in conjunction with this instrument will enable the NCI to follow the production of lactate in tumor and normal tissue both before and after exposure to ionizing radiation. Lactate production has been shown to be a good indicator of hypoxia and tissue response to cytotoxic agents. The hyperpolarization of the C13 labeled compounds will allow for the unprecedented detection of these compounds in in-vivo systems (mouse, rabbits and eventually humans) using standard MRI pulse sequences. The ability to use this instrument in animal models should provide important information that will lead to human clinical trials. Oxford Instruments worked closely with GE Medical to produce the Hypersense instrument to work with the proprietary Trityl radical, which is needed to activate the 13C-labeled pryuvate so that the appropriate metabolic by-products can be followed. It is not known to the NCI that any other manufacturer has access to the Trityl radical and hence is unable to make this instrument. This is not a solicitation for competitive quotations. However, if any interested party believes they can meet the above requirement, they may submit a statement of capabilities. All information furnished shall be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI contracting office by 1:00 PM ET on June 21, 2007. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Malinda Holdcraft, Contract Specialist at holdcram@exchange.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference NCI-70066-NG on all correspondence.
- Record
- SN01315476-W 20070613/070611220253 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |