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88 -- A Repository of Mouse Models for Cytogenetic Disorders

Notice Date
Notice Type
Sources Sought
112990 — All Other Animal Production
Contracting Office
Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, MD, 20892-7510, UNITED STATES
ZIP Code
Solicitation Number
Response Due
Archive Date
The National Institute of Child Health and Human Development (NICHD) has a requirement for continuing development of a repository for the production, maintenance, and distribution of aneuploid mice. This work is currently being conducted under contract number N01-HD-7-3265 with The Jackson Laboratory, Bar Harbor, Maine. The NICHD intends to continue this contract with The Jackson Laboratory by using other than full and open competition. The purpose of the contract is to refine methodologies to produce segmental (partial) trisomies and improve the production of chimeric mice with a trisomy 16 component. More specific responsibilities will include breeding various strains of mice to produce trisomic or monosomic embryos with emphasis on chromosome 16; freezing, rescuing, and re-implanting embryos into pseudo-pregnant mice; continued development of methods to improve the production of chimeric mice with a trisomic component; and distribution the mice to requestors. Emphasis will also be made on the production, characterization, and distribution of a single gene transgenics and YAC and BAC transgenics utilizing segments of human chromosome 21. The current contractor is uniquely qualified to perform the job and is the only facility now with the capacity to produce required partially trisomic and monosomic mice in quantities and with uniformity suitable for the research community at large. The organization must have successful past performance breeding, maintaining, and distributing mice that produce partial trisomy with special emphasis on Ts65Dn. In addition, the organization must have successful past performance in freezing embryos and implanting them into pseudo-pregnant mice to produce viable progeny. The organization must have adequate and available facilities and equipment for satisfactory performance of the statement of work. The NAICS code is 112990. The determination to use other than full and open competition was made in accordance with 41 USC 253 ? (1), FAR 6.302-1. The purpose of this synopsis is to determine whether there are other sources capable of meeting the Government?s requirements as described above. Capability statements should be submitted by May 1, 2007 and should include details specifying how they would carry-out this work. Capability statements should be submitted to Mrs. Mya N. Hlaing, NIDDK/NIH, CMB, Executive Building, Room 7A-07, MSC 7510, Bethesda, MD 20892-7510. Capability statements should not be more than ten (10) pages and electronic copies will not be accepted. Please send original plus three (3) copies without resume. If it is an express mail, the last line of the address should be Rockville,MD 20852. See Numbered Note 22.****
SN01251724-W 20070317/070315220554 (fbodaily.com)
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