SOLICITATION NOTICE
A -- Reproductive Assessment in Rodents
- Notice Date
- 4/13/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Environmental Health Sciences, Office of Acquisitions, Office of Management P.O. Box 12874, 79 T.W. Alexander Dr, Bldg 4401, RTP, NC, 27709
- ZIP Code
- 27709
- Solicitation Number
- NIH-ES-06-06
- Response Due
- 6/1/2006
- Point of Contact
- Juanita Campbell, Contract Specialist, Phone 919-541-7893, Fax 301-451-5597, - Latise Lewis, Procurement Technician, Phone 919-541-7950, Fax 919-541-2712,
- E-Mail Address
-
campbellj@niehs.nih.gov, lewisl@niehs.nih.gov
- Description
- This Notice announces the intended release of solicitation number NIH-ES-06-06 (FULL AND OPEN COMPETITION). (This requirement was previously solicited under NIH-ES-06-02/NIH-ES-06-02A (SMALL BUSINESS SET -ASIDE). The National Institute of Environmental Health Sciences (NIEHS) is soliciting proposals for testing of environmental agents, and analyzing/evaluating testicular and sperm tissues/slides and vaginal cytology tissues/slides from toxicity tests of environmental agents as identified by the National Toxicology Program (NTP), the Environmental Protection Agency (EPA), and other regulatory agencies. Environmental agents shall be tested for their potential reproductive toxicity in in-vivo rodent models. Task 1 Reproductive Assessment By Continuous Breeding (RACB) - Environmental agents shall be tested for their potential reproductive toxicity in "in vivo" rodent models. The contractor shall conduct multigeneration reproductive studies involving the testing of approximately 10 environmental agents per year, using the RACB protocol. The Contractor shall have: animal facilities large enough to house 1500 rat cages with specific pathogen free (SPF) barrier conditions; capability and experience conducting Good Laboratory Practice (GLP) compliant multigeneration reproductive toxicology studies in rats and mice; and an Institutional Animal Care and Use Committee (IACUC). The contractor shall conduct histopathology evaluations on reproductive and other target organs, as well as crossover mating of animals. The laboratory and/or personnel should have prior experience in evaluating endocrine disruption endpoints and conducting dominant lethal tests. The Contractor shall comply with the following guidance/regulatory requirements: The Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) accreditation; NTP Health and Safety Minimum Requirements for Off-Site Contractors; NTP Laboratory Animal Management Specifications; NTP Test Article Requirements for Toxicology Testing Laboratories; NTP Good Laboratory Practice Standards (GLPS) for Study Conduct; FDA GLP Regulations for Non-Clinical Laboratory Studies; and applicable Federal, State, and Local Laws. Task 2 Sperm Count and Vaginal Cytology Evaluations (SCVCE) - The Contractor shall: 1) Analyze/evaluate testicular and sperm tissues/slides, and vaginal cytology tissues/slides from toxicity tests of environmental agents; 2) Evaluate the effects of environmental agents on the reproductive tissues of laboratory animals (specifically mice or rats), and report the results of these evaluations; 3) Develop protocols and reports; and 4) Provide technical procedures/training for personnel at designated toxicology laboratories. Training shall include procedures/topics such as optimal methods of assessing sperm motility and velocity measurements by computer assisted semen analyzer (CASA), and optimization of methods for preparing vaginal cytology slides. The Contractor shall have capability and experience in conducting GLP compliant reproductive toxicology studies with an SCVCE Component. The Contractor shall comply with the following guidance/regulatory requirements: The NTP Health and Safety Minimum Requirements for Off-Site Contractors; The NTP Good Laboratory Practice Standards (GLPS) for Study Conduct and the FDA Good Laboratory Practice Regulations for Non-Clinical Laboratory Studies; and applicable Federal, State, and Local Laws. Unless otherwise specified in the solicitation, the offeror may submit a proposal for either Task 1 or Task 2, or both Task 1 and Task 2. It is anticipated that one (1) or two (2) cost reimbursement, multiple year, completion and/or level of effort type award(s) will be made, with an anticipated award date of September 30, 2006. The Government anticipates that the estimated level of effort shall be approximately 39,860 direct labor hours per year (Task 1 - 35,500 hours, and Task 2 - 4,360 hours). The period of performance is expected to be five (5) years with a possibility for the inclusion of "special studies" options under Task 1. The anticipated release date of the RFP is on or about April 28, 2006, with proposals due on or about June 1, 2006. Interested firms should telefax a request for RFP NIH-ES-06-06 to the attention of Ms. Juanita A. Campbell, Contract Specialist, at (301) 451-5597, or e-mail a request to campbellj@niehs.nih.gov. Electronic versions of the RFP will be available at http://www.niehs.nih.gov/dert/rcb/rfp.htm. See numbered note 26. NOTE: THIS NOTICE MAY HAVE POSTED ON FEDBIZOPPS ON THE DATE INDICATED IN THE NOTICE ITSELF (13-APR-2006). IT ACTUALLY APPEARED OR REAPPEARED ON THE FEDBIZOPPS SYSTEM ON 02-OCT-2006, BUT REAPPEARED IN THE FTP FEED FOR THIS POSTING DATE. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
- Web Link
-
Link to FedBizOpps document.
(http://www.fbo.gov/spg/HHS/NIH/NIEHS/NIH-ES-06-06/listing.html)
- Record
- SN01160130-F 20061004/061002222144 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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