SOLICITATION NOTICE
66 -- Whole Genome Genotyping Kits and Gene Expression System
- Notice Date
- 8/22/2006
- Notice Type
- Solicitation Notice
- NAICS
- 238990
— All Other Specialty Trade Contractors
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Office of Administration, 6011 Executive Blvd, Rm 538, Rockville, MD, 20892-7663
- ZIP Code
- 20892-7663
- Solicitation Number
- 263-2006-Q-(DV)-0191
- Response Due
- 8/28/2006
- Archive Date
- 9/12/2006
- Description
- The National Institutes of Health (NIH) intends to negotiate on a sole source basis with Illumina, Inc. 9885 Towne Center Drive, San Diego, CA 92121. Illumina, Inc. is uniquely qualified to supply the gene expression microarray system and required whole-genome genotyping kits to the National Institute on Aging (NIA). Illumina, Inc. is the only known source with the experience of supplying genotyping kits for over 500,000,000 genotypes in 1100 individuals using NIA existing equipment and the required ease of use, and high reproducitbility, gene expression microarray system in part, due to the presence of multiple copies of individual genes present on each array, with a feature number of approximately 1.6 million on each array surface of the beadarray slide. The Illumina logoligo beadarray offer resolution of less than 1 micro, compared with resolution of 5 micron for others. The Illumina longoligo beadarray system offers the use of a single fluorescent dye, Cy3, instead of the two different dyes necessary for other longoligo arrays. The contractor shall perform in accordance with the following specifications: Salient Characteristics Human Whole-Genome Genotyping Kit 1. shall be genotyping chips of high density second generation SNP genome chips that have a proven record of quality. 2. shall be capable of being used to assay a single individual for greater than 100,000 SNPs. 3. shall include all reagents associated with chips to perform wet-lab experiments. 4. shall be capable of being used in the molecular genetic investigations of neurological disease and in the determination of genotyping at a density of greater than 100,000 SNP assays peer individual. 5. shall be capable of being used to identify genetic variability associated with neurological disease and in defining the extent of normal genetic variability associated with lifetime risk for Parkinson's disease and related disorders. 6. shall be capable of being used to identify genetic variability associated with neurological disease and in defining the extent of normal genetic variability associated with lifetime risk for stroke. 7. shall be capable of being used to identify genetic variability associated with neurological disease and in defining the extent of normal genetic variability associated with lifetime risk for amyotropic lateral scierosis. Salient Characteristics: Gene Expression Array System 1. shall be a gene expression microarray system. 2. shall include scanner with resolution of 0.8 micron or bettr, image acquisition and extraction software, automated genotype calling software, detailed operating procedures and documentation. 3. shall include bead array reader, PC with 17 inch flat-screen monitor, expression analysis software (minimum 5 licenses), minimum two (2) array matrix hybridization chambers, minium three (3) hybridization cartridges, hybridization oven, and user documentation. 4. shall include on-site training for minimum 5 technicians on the expression protocols including sample preparation, array hyridization, scanning and data analysis at no additional cost to the Government. 5. shall include a one (1) year parts and labor warranty that includes a scheduled preventative maintenance visit, system upgrade support, travel cost, and replacement parts including laser replacement and realignment, if needed at no additional cost to the Government. 6. shall support assays/applications of whole genome expression and custom and standard focused set expression. 7. shall support analysis formats of microarray in Array of Arrays formats, allowing multi-sample processing of up to 96 samples in parallel, and up to 16 samples in parallel. 8. shall include sample preparation such that samples can be prepared manually or with automation using industry standard liquid handling robotics. 9. shall be capable of throughput per 8 hours (one technician) of 6 to 384 samples or better. 10. shall include daily throughput (one technician) of up to 48 whole human genome samples (48,000 genes per sample) or better and up to 384 focused set samples (200-700 genes per sample)or better. 11. shall be capable of a minimum smaple input of 50ng (280pg/gene analyzed) total RNA per sample, or better. 12. shall be capable of total processing time (sample to data) of 3 days or better. This proposed action is for items for which the Government intends to solicit and negotiate with only one source. Interested parties may identify their interest and capability to respond to the requirement or submit proposals. The notice of intent is not a request for competitive quotations. However all quotes received within five days after the date of publication of this will be considered by the Government. A determination by the Government not to compete this proposed simplified acquisiiton requirement based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considerd solely for the purpose of determining whether to conduct a competitive acquisition.
- Place of Performance
- Address: 9885 Towne Center Drive, San Diego, CA
- Zip Code: 92121
- Country: UNITED STATES
- Zip Code: 92121
- Record
- SN01121824-W 20060824/060822220437 (fbodaily.com)
- Source
-
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