SPECIAL NOTICE
A -- ARGONNE, BROOKHAVEN, LOS ALAMOS, OAK RIDGE & PACIFIC NORTHWEST NATIONAL LABORATORIES ANNOUNCE INTENT TO APPLY TO DEVELOP USER FACILITY TO PRODUCE AND CHARACTERIZE PROTEINS AND MOLECULAR TAGS
- Notice Date
- 3/9/2006
- Notice Type
- Special Notice
- NAICS
- 238990
— All Other Specialty Trade Contractors
- Contracting Office
- Department of Energy, Argonne National Laboratory (DOE Contractor), Argonne, 9700 S. Cass Avenue, Argonne, IL, 60439
- ZIP Code
- 60439
- Point of Contact
- Lee Makowski, Director - Biosciences Division, Phone (630) 252-3819, Fax (630) 252-3853, - Joseph Ingraffia, Procurement Services Manager, Phone 630-252-3640, Fax 630-252-4517,
- E-Mail Address
-
lmakowski@anl.gov, jingraffia@anl.gov
- Description
- ARGONNE NATIONAL LABORATORY, BROOKHAVEN NATIONAL LABORATORY, LOS ALAMOS NATIONAL LABORATORY, OAK RIDGE NATIONAL LABORATORY AND PACIFIC NORTHWEST NATIONAL LABORATORY ANNOUNCE THE INTENT TO APPLY TO DEVELOP USER FACILITY TO PRODUCE AND CHARACTERIZE MICROBIAL PROTEINS AND MOLECULAR TAGS Announcement: The Protein Science Consortium (PSC) is a cooperative association of the Argonne National Laboratory (ANL), Brookhaven National Laboratory (BNL), Los Alamos National Laboratory (LANL), Oak Ridge National Laboratory (ORNL) and Pacific Northwest National Laboratory (PNNL). ANL is a government-owned/contractor operated (GOCO) facility managed by the University of Chicago, for the U.S. Department of Energy (DOE). BNL, ORNL and PNNL are government owned/contractor operated (GOCO) facilities managed by Battelle. LANL is a national security laboratory managed as government-owned, contractor-operated (GOCO), federally funded research and development centers (FFRDCs) by the University of California under contract with the U.S. Department of Energy (DOE)/National Nuclear Security Administration (NNSA). As the five national laboratories are each federally funded research and development centers, each laboratory and the PSC is bound by fairness of opportunity requirements and Federal Acquisition Regulations (FARs). The Genome to Life program (GTL) in the Office of Biological and Environmental Research (OBER) of the Office of Science, U. S. Department of Energy (DOE) has released a draft RFP for a GTL Facility for the Production and Characterization of Protein and Molecular Tag, Funding Opportunity No. DE-PN02-06ER64154 https://e-center.doe.gov/iips/faopor.nsf/UNID/036C90C51E5B565685257111007D1111/$file/GTL+PN0206ER64154+GrantsGov+Feb+10+Amd+001.pdf The Facility for the Production and Characterization of Proteins and Molecular Tags, will surmount a principal roadblock to whole-system analysis of biomolecular networks that is the foundation for the entire GTL program by implementing high-throughput production and characterization of microbial proteins. This Facility will bring together, for the first time, comprehensive technologies to mass-produce and characterize microbial proteins directly from sequence data and to generate specific 'capture and labeling' affinity reagents for each protein. The availability of these characterized proteins and "tags" to capture, identify, and track them in living systems will provide a crucial resource for researchers. This will enable development of methods to determine how and under which condition these proteins and protein complexes function in cellular processes. The development of this facility will require additional research to develop the core technologies that will underpin the capabilities of the Facility including the development of technologies for high-throughput production of proteins and their biophysical characterization, and for the production of molecular tags to identify individual proteins and to characterize multi-protein complexes in microbial cells. Production and characterization technologies should be scalable, economic, and sufficiently robust to work in a production environment. At least 50% of all proteins are anticipated to pose significant problems for any current production method. Consequently, a significant component of this project will be research into new methods of protein production. Improved techniques are also needed to predict from genome sequence what production and purification approaches are most likely to succeed with each protein. Thus, informatics also is an integral component. Algorithms based on data from successful and failed protein expressions are expected to substantially inform and improve future protein production efficiency. The Facility will produce, characterize, and make available a wide range of microbial proteins from both cultivated and uncultivated microbes for use by the scientific community in their individual research projects. Ready availability of these resources will free the nation's scientists to apply their energies to understanding these microbes, a major step toward using microbial capabilities. For parties interested in supporting and/or working with the PSC on the proposed user facility for the Production and Characterization of Proteins and Molecular Tags, please respond in writing to the PSC byApril 4, 2006 addressing each of the items listed below. PSC will respond back by April 11, 2006. 1. Name, location(s) and descriptions including a. Recent annual report or other overview of your organization and the team that you are proposing in response to the draft RFP b. Experience relevant to the Production and Characterization of Proteins and Molecular Tags c. Experience with Department of Energy and National Laboratories 2. Point of contact with title, address, phone, and email NOTE: THIS NOTICE MAY HAVE POSTED ON FEDBIZOPPS ON THE DATE INDICATED IN THE NOTICE ITSELF (09-MAR-2006). IT ACTUALLY APPEARED OR REAPPEARED ON THE FEDBIZOPPS SYSTEM ON 24-JUL-2006, BUT REAPPEARED IN THE FTP FEED FOR THIS POSTING DATE. PLEASE CONTACT fbo.support@gsa.gov REGARDING THIS ISSUE.
- Web Link
-
Link to FedBizOpps document.
(http://www.fbo.gov/spg/DOE/ANL/AN/Reference-Number-JI03102006/listing.html)
- Record
- SN01096909-F 20060726/060724223042 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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