SOLICITATION NOTICE
B -- Clinical Research Support Services
- Notice Date
- 6/15/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-PB-(HL)-2006--222-DDC
- Response Due
- 6/30/2006
- Archive Date
- 7/15/2006
- Description
- THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR A PROPOSAL. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND PROPOSALS WILL NOT BE REQUESTED. The National Heart, Lung, and Blood Institute?s (NHLBI) Consolidated Operations Acquisition Center (COAC), intends to negotiate and award a purchase order on a noncompetitive sole source basis to the Ahmadu Bello University Teaching Hospital-Abuth, PMB 1026 Shika Zaria, Kaduna State, Nigeria, to provide clinical research support services for the Prevalence of Secondary Pulmonary Arterial Hypertension (PAH) in Patients with Sickle Cell Disease in Nigeria and the Role of HIV/AIDS and Endemic Parasitic Infections in the Natural History of Pulmonary Hypertension in Sickle Cell Disease study. Sickle cell disease (SCD) is an autosomal recessive disorder and the most common genetic disease in the world. It is the most common inherited blood disorder in the United States, affecting more than 70,000 Americans resulting in significant physical and psychosocial morbidity and premature mortality. A major organ complication of SCD is secondary pulmonary arterial hypertension (PAH). Many known infectious risk factors for (PAH) are also highly prevalent in Nigeria, including Human Immuno Deficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS), malaria, chronic hepatitis B and C, schistosomiasis and hookworm. The overall goal of this project is to determine the prevalence of secondary, pulmonary hypertension in Nigerian patients with sickle cell anemia. The project aims to determine the prevalence of HIV, malaria, hepatitis B and C, schistosomiasis and hookworm in Nigerian patients with sickle cell anemia, and the interaction of HIV, malaria, hepatitis B and C, schistosomiasis, hookworm, and sickle cell anemia in (PAH) in Nigerian patients with sickle cell anemia. And to confirm a genetic diagnosis for sickle ?-globin syndromes and ?-thalassemia syndromes in this cohort as a point of reference for future genotype-phenotype studies, and using both candidate gene and genome wide association approaches, NHLBI along with ABUTH will identify and selectively characterize single nucleotide polymorphisms (SNPs) in genes important for endothelial function and vascular inflammation, and identifying genetic proteomic risk factors associated with pulmonary hypertension in SCA using this study?s genotyping approaches. The sole source determination is based upon the fact that the Ahmadu Bello University Teaching Hospital(ABUTH) in Zaria, Nigeria is the only known source that is currently able to assist the NIH, NHLBI, Vascular Medicine Branch in this area of research. An award to any other source would result in a substantial duplication of cost to the Government that is not expected to be recovered through competition. The expected period of performance is one (1) year from the date of the award. This acquisition is being conducted under simplified acquisition procedures and is exempt from the requirement of Federal Acquisition Regulations (FAR) Part 6, Competition Requirements. The North American Industry Classification System (NAICS) applicable to this requirement is
- Place of Performance
- Address: BETHSDAY MD
- Zip Code: 20892-7902
- Country: USA
- Zip Code: 20892-7902
- Record
- SN01070470-W 20060617/060615220745 (fbodaily.com)
- Source
-
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