SOLICITATION NOTICE
R -- Dermal Absorption of DEET in Soil
- Notice Date
- 6/7/2006
- Notice Type
- Solicitation Notice
- Contracting Office
- Environmental Protection Agency, National Procurement Contract Service Center, 1200 Pennsylvania Avenue, Nw 3803r, Washington, DC 20460
- ZIP Code
- 20460
- Solicitation Number
- RFQ-DC-06-00303
- Response Due
- 6/22/2006
- Archive Date
- 7/22/2006
- Description
- NAICS Code: 541620 Notice of intent to award a sole source purchase order under the procedures in FAR 8.4 to Dr. John Kissel, University of Washington, Seattle, WA 98195 . Applicable NAICS code is 541620. The effort to be performed is outlined below. Dr. Kissel has conducted dermal absorptions studies in vivo and in vitro previously and has developed the protocols and procedures required to conduct analyses of DEET for this purchase order. Few laboratories conduct dermal absorption studies. Of those most have developed procedures in a particular species such as swine at the North Carolina State University or primates at the University of California at San Francisco. Others use surgically obtained human skin routinely such as the Colorado School of Mines. Most of these laboratories prefer to use in vitro test systems because they are cheaper and easier than dealing with in vivo test systems. Importantly few of these investigators have sufficient expertise with conducting dermal absorption studies using contaminated soil. Proper soil classification to describe mineral components, particles sizes, organic content and moisture and sample preparation is essential to prepare soil samples properly for dermal absorption studies. Prior to investigations in NCEA, investigators consistently failed to classify and prepare soil samples correctly which led to considerable errors in reports of their results in the literature. Dr. Kissel is a well know international expert on dermal absorption from chemically contaminated soil and to our knowledge Dr. Kissel is the only investigator who routine conducts dermal absorption studies of chemically contaminated soil in vivo and in vitro. This makes his procedures unique compared to other investigators in this field. Additionally Dr. Kissel has conducted work in previous studies under Cooperative Agreement #82963201 entitled AReview and evaluation of models of dermal absorption@. Under this cooperative research agreement Dr. Kissel has reviewed the dermal absorption literature for chemically contaminated water and soil. He has evaluated dermal absorption protocols and models used to estimate dermal exposure. Thus, he has completed a substantial component of the work required to conduct dermal absorption analyses of DEET previously. Because Dr. Kissel has unique knowledge about dermal absorption of chemically contaminated soil and has investigated the procedures required to conduct analyses of DEET, he is the logical choice to conduct these analyses in DEET. STATEMENT OF WORK I. Background Dermal absorption from chemical contaminants in soil/sediment A variety of models are in use today to estimate the dermal absorption of chemicals from soils and water. The accuracies of these models are widely questioned and the uncertainties/limitations not well understood. The central reason for this problem is the lack of appropriate experimental data which can be used to develop and test these models. The problems with the data currently available include the use of experimental conditions which poorly represent actual exposure conditions and the difficulties in extrapolating in vitro or animal in vivo data to humans. The purpose of this project is to conduct dermal absorption studies to support development of these models. The work will have the double benefit of helping the scientific community understand how to 1) conduct more useful dermal experiments and 2) evaluate/improve current dermal absorption models. The structure for a soil model has not been established. Current research is focused on the release of contaminants from soil to skin. Investigations have been conducted to identify how chemical releases are influenced by contaminant concentrations, soil type, soil conditions, and soil loading amounts/patterns. These experiments identified the important factors and permit development of a model to predict chemical releases to skin. In vitro methods, using artificial skin surrogates and cadaver skin have been investigated to identify the factors and release rates of contaminants from soil to skin. The purpose of this project is to conduct in vivo dermal absorption studies using soil contaminated with DEET and to compare these results to dermal absorption studies conducted with in vitro procedures. Ultimately, the results of these studies will be used with information available about chemical release from soils and sediments to develop a dermal absorption model for chemically contaminated soil. II. Scope of Work The contractor shall develop a report about in vivo dermal absorption of DEET. The report shall contain: 1. the protocol used to prepare chemically contaminated soil and test dermal absorption in vivo using DEET, 2. the results of the individual analyses with summary statistics, 3. a comparison of these results with in vitro dermal absorption studies of soil contaminated with DEET to ascertain differences and, 4. development of a dermal absorption model for chemically contaminated soil. III. Deliverables and Professional Services Deliverables/Meetings Anticipated Completion Dates Provide a report that contains the protocol, 120 days after award procedures, results, analyses and model as described in the Scope of Work. The Contractor shall report to the NCEA Technical Project Officer (TPO) on a weekly or daily basis as needed. The Contractor shall not release any of the data collected in this study nor publish any of the results of this work without the written consent of the TPO. THIS IS NOT A REQUEST FOR QUOTATION. No contract will be awarded on the basis of offers received in response to this notice. All inquiries and concerns must be addressed in writing to US EPA, Attn: Paul Dawson (3803R), 1200 Pennsylvania Ave NW, Washington , DC 20460, or sent by email to dawson.paul@epa.gov. Telephone requests or inquiries will not be accepted. Responses to this notice must be submitted within fifteen (15) days after this electronic posting. A determination not to compete this requirement is within the discretion of the Government. Any response to this notice must show clear and convincing evidence that competition would be advantageous to the Government in future procurements
- Record
- SN01064468-W 20060609/060607222032 (fbodaily.com)
- Source
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