SOLICITATION NOTICE
R -- Nasal gas-phase mass
- Notice Date
- 3/7/2006
- Notice Type
- Solicitation Notice
- Contracting Office
- Environmental Protection Agency, Program Contract Service Center, 1200 Pennsylvania Avenue, Nw, Washington, DC 20460
- ZIP Code
- 20460
- Solicitation Number
- RFQ-DC-06-00182
- Response Due
- 3/22/2006
- Archive Date
- 4/22/2006
- Description
- NAICS Code: 541990 NAICS code 541990: The U.S. Environmental Protection Agency (EPA) plans to negotiate on a sole source basis with Dr. Julie Kimble of CIIT Centers for Health Research. Negotiations shall be conducted pursuant to the authority of 41 U.S.C. 253 (c)(1), which allows for negotiations without full and open competition if there is only one responsible source. The basis of this determination is that the U.S. EPA, National Center for Environmental Assessment, previously awarded a Purchase Order, 2RN018-QT-0H-05-000006 and Cooperative Agreement CR 820429 to Dr. Kimble. The National Center for Environmental Assessment (NCEA) of the Environmental Protection Agency proposes this project to assure accurate estimates of dosimetry to nasal tissue in rats, obtained using so-called hybrid computational fluid dynamics (CFD)-physiologically based pharmacokinetic (PBPK) models, since these estimates are being proposed with greater frequency as the basis for dose-metric extrapolation of inhalation toxicity endpoints from rats to humans. Within such hybrid CFD-PBPK models, a set of constants which define the air-phase resistance to mass transfer (denoted kGs) were previously estimated using an incomplete CFD model of the rat nose and in some cases appear to have been inappropriately integrated into the CFD-PBPK models due to the way multiple resistances were quantified. Since 1) nasal tissues are fairly often targets of inhaled toxic compounds; 2) hazard and dose-response data for such endpoints are often obtained in experimental studies with rats; and 3) it is EPA's goal to make use of the best available science, we seek to update these kGs using the improved, complete rat nasal CFD models now available. This specific project will also implement a procedure where the simulated absorption of a gas in the anterior portion of the rat nose is set to zero when estimating gas-phase resistance in posterior regions to avoid numerical instability and inaccuracy that otherwise can occur. Thus it will utilize state-of-the-science methods to estimate dosimetry parameters in an important test species. The contractor will accomplish this work using existing rat CFD models which they have already developed independently. The published results of this project could potentially be applied directly to Agency inhalation dosimetry and to risk assessment procedures for inter-species extrapolation. The National Center for Environmental Assessment is seeking to contract with Dr. Julia Kimbell of the CIIT Centers for Health Research to provide expertise in the highly specialized area of application of inhalation dosimetry in the respiratory tract to address issues of test-animal dosimetry estimation for use in inter-species extrapolation. Through her current work, Dr. Kimbell has developed a body of intellectual property in the form of unique, sophisticated, computational models that describe inspired air flow in areas of the respiratory tract relevant for risk assessment. These models have been developed for rats as well as monkeys and for a number of individual humans using anatomically accurate reconstructions of nasal anatomy. These models therefore provide a unique opportunity to accurately predict regional dosimetry in both experimental animals and humans. Although the information on these models have been or will be published, the specific computational analyses needed to update the gas phase mass transfer resistances have not been performed and are otherwise not being planned. Dr. Kimbell possesses highly developed skills in application, conduct, and interpretations of results from such models. Thus, Dr. Kimbell is uniquely qualified and situated to meet the Agency's needs and to perform this work in a cost-effective and efficient manner. This notice of intent is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to the requiring by submitting documentation, to Thomas Martinez at the office identified above, by fax (703)308-2358 or by e-mail (Martinez.Thomas@epa.gov) , which establishes that their specifications meet EPA's requirement. Documentation must be received within fifteen (15) days after the date of publication of this synopsis to be considered by EPA. A determination not to compete this proposed contract based upon responses to this notice is solely within the discretion of the government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement.
- Record
- SN01001712-W 20060309/060307212559 (fbodaily.com)
- Source
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