SOLICITATION NOTICE
A -- SNP Health Association REsource (SHARE)
- Notice Date
- 2/17/2006
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-PB-2006-091
- Response Due
- 3/27/2006
- Archive Date
- 3/27/2006
- Description
- The National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), seeks a contractor to provide high-quality, large-scale, Single Nucleotide Polymorphism (SNP) genotyping including, but not limited to, obtaining the samples, ordering the genotyping assays, obtaining reagents, genotyping SNP?s, repeating failed genotyping reactions, genotyping additional SNP?s to compensate for those that failed, assessing genotype quality, analyzing the data to produce a clean data set, transferring the data, and indirect, facilities, and/or administration services. The overall objective of this acquisition is to identify genetic variants associated with Heart, Lung, Blood and Sleep (HLBS) disorders and diseases through the application of large-scale genotyping for genome-wide association analyses. In collaboration with the National Center for Biotechnology Information (NCBI), the NHLBI is developing a data resource that will integrate genome-wide genotypic information with phenotypic information from multiple NHLBI studies. Following its development, access will be provided to the scientific community to perform genome-wide association analyses and thus identify genetic variants that are correlated with HLBS disorders and diseases. The Contractor shall perform the following four major tasks: 1) sample receipt and handling; 2) large-scale genotyping of a panel of 500,000 (500K) or more assays, including quality control measures during production to identify genotyping errors and sample mix-ups in up to approximately 16,200 samples from designated NHLBI studies; 3) data cleaning, including but not limited to checks for Hardy-Weinberg equilibrium and Mendelian inconsistencies; and, 4) transfer of each of the completed and cleaned data sets to the NCBI for data integration and ultimately data dissemination. Specific Minimum Technical Requirements: The Contractor shall: 1) provide personnel with expertise and experience in large-scale genotyping, general laboratory management, and Quality Control (QC); 2) provide personnel with expertise and experience in sample receipt, tracking, handling and storage; develop and implement procedures for these activities; 3) provide personnel with expertise and experience in genetic analyses for data cleaning; 4) provide personnel with expertise and experience in the secure transfer of large-quantities of genetic data; 5) provide raw data and coding information to the Project Officer; 6) provide status reports; 7) maintain the confidentiality of the data received or produced; 8) provide secure backup of all data essential to the project, including but not limited to all genotyping data generated, study data received, sample tracking and storage information, and QC information; 9) receive and process data and samples from designated NHLBI studies, including: a. verify and obtain records of Institutional Review Board approval for the study prior to accepting samples for genotyping; 10) receive, track, and store from approximately 9,000 samples DNA samples and accompanying data in preparation for genotyping; 11) initiate genotyping of a panel of 500K or more assays on all samples received (approximately 9,000) within the first two months of contract award; 12) complete genotyping of the 500K or more panels on all samples received, including quality control measures during production to identify genotyping errors and sample mix-ups within 6 months of initiation of the of genotyping. Options for an additional 7,200 samples may be exercised. The Contractor must be approved for handling human DNA. Contract employees in contact with human DNA or data derived from these human subjects must provide Certification of Human Subjects Training prior to a contract award. Further information regarding the requirement is discussed in detail in the Statement of Work (SOW). The intended procurement will be classified under North American Industry Classification System (NAICS) code 541710, Research and Development in the Physical, Engineering, and Life Sciences, with a size standard of 500 employees. The Government anticipates that there will be a single contract awarded for this requirement. A eight (8) month period of performance is anticipated, with two additional eighteen month options. The planned release date of the solicitation document is on or about February 24, 2006, with a due date of March 27, 2006. The planned contract award date is September 1, 2006. Interested parties must submit a written request for a copy of solicitation number NHLBI-PB-2006-091 to the National Heart, Lung, and Blood Institute, Office of Acquisitions, Procurement Branch, Rockledge Building 2, Suite 6042, 6701 Rockledge Drive, Bethesda, Maryland 20892-7902. Telephone number: (301) 435-0366, fax number (301) 480-3345, Attention: Jeffrey Curry. Written requests may be submitted by fax to (301) 480-3345 or by e-mail to curryj@nhlbi.nih.gov.
- Place of Performance
- Address: National Heart, Lung, and Blood Institute, 31 Center Drive, Bethesda, Maryland
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN00990459-W 20060219/060217211922 (fbodaily.com)
- Source
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