SPECIAL NOTICE
A -- TECHNOLOGY/BUSINESS OPPORTUNITY
- Notice Date
- 12/7/2005
- Notice Type
- Special Notice
- NAICS
- 238990
— All Other Specialty Trade Contractors
- Contracting Office
- Department of Energy, Lawrence Livermore National Laboratory (DOE Contractor), Industrial Partnerships & Commercialization, 7000 East Avenue L-795, Livermore, CA, 94550
- ZIP Code
- 94550
- Solicitation Number
- Reference-Number-FBO116-06
- Response Due
- 1/9/2006
- Archive Date
- 1/10/2006
- Description
- TECHNOLOGY/BUSINESS OPPORTUNITY IN VIVO IMAGING OF TISSUE MICROSTRUCTURES AND CELLS Opportunity: Lawrence Livermore National Laboratory (LLNL), operated by the University of California under contract with the U.S. Department of Energy (DOE), is offering the opportunity to license a hyperspectral/multimodal microscope for in vivo imaging of living cells in a clinical setting. Background: The gold standard in viewing the structure of living cells is light microscopy on a fixed tissue section. However, this requires removal of tissue from the patient (ex vivo), and the time required for tissue processing results in significant delays. Description: Using various excitation wavelengths, a hyperspectral microscope takes advantage of autofluorescence and polarized light scattering from cellular components to obtain composite images that highlight their presence. The light collection efficiency is maximized to achieve image acquisition times and rates suitable for in vivo applications. Advantages: This technology employs the benefits of multi-dimensional spectroscopic imaging at the micro-scale but without the complexity of nonlinear microscopy or the costs, complexity, and signal loss of confocal microscopy. Apply in vivo in clinical settings Non-invasive to cells Provide fast, real-time imaging and monitoring of living cells Incorporate a large variety of optical imaging approaches Minimal operational complexity Can be made portable Potential Applications: Microscopic imaging tool to assist during surgery Monitoring tissues or organs during testing of specific drugs or after exposure to adverse conditions, e.g., radiation Development Status: A prototype of the hyperspectral microscope is located at the University of California Davis Medical Center. The U.S. patent application has been filed for this invention. LLNL is seeking industry partners with a demonstrated ability to bring such inventions to the market. Moving critical technology beyond the Laboratory to the commercial world helps our licensees gain a competitive edge in the marketplace. All licensing activities are conducted under policies relating to the strict nondisclosure of company proprietary information. Please visit the IPAC website at http://www.llnl.gov/IPandC/workwithus/partneringprocess.php for more information on working with LLNL and the industrial partnering and technology transfer process. Note: THIS IS NOT A PROCUREMENT. Companies interested in commercializing LLNL's Hyperspectral Microscope should provide a written statement of interest, which includes the following: 1. Company Name and address. 2. The name, address, and telephone number of a point of contact. 3. A description of corporate expertise and facilities relevant to commercializing this technology. Written responses should be directed to: Lawrence Livermore National Laboratory Industrial Partnerships and Commercialization P.O. Box 808, L-795 Livermore, CA 94551-0808 Attention: FBO 116-06 Please provide your written statement within thirty (30) days from the date this announcement is published to ensure consideration of your interest in LLNL's Hyperspectral Microscope.
- Record
- SN00947334-W 20051209/051207211924 (fbodaily.com)
- Source
-
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