SOLICITATION NOTICE
B -- High quality, genome wide scan of high density Single Nucleotide Polymorphisms
- Notice Date
- 10/25/2005
- Notice Type
- Solicitation Notice
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bldg 427, Room 12, Frederick, MD, 21702
- ZIP Code
- 21702
- Solicitation Number
- Reference-Number-S02-076
- Archive Date
- 12/31/2005
- Description
- SAIC-Frederick, Inc., Prime Contractor to the NCI Frederick Cancer Research Facility will be issuing a Request for Proposal for this project on or about 10/26/05. If you wish to receive a copy of the solicitation when it is issued, please contact Jeanne Lewis at jlewis@ncifcrf.gov. To help meet the Challenge Goal of eliminating suffering and death from cancer by 2015, the NCI is capitalizing on the extraordinary momentum generated by advances in human genetic research. The sequencing of the human genome and the annotation of common variations, together with new technologies for analyzing SNPs, have provided the tools for investigators to actively search for inherited variants in genes that increase or decrease cancer risk. The convergence of sequencing the human genome, rapid progress in the International HapMap project, and the development of technologies that permit very large-scale SNP genotyping has made it possible to execute well-designed association studies using common variants across the entire genome to map low-penetrant genes involved in cancer susceptibility. The results of such studies are expected to open new vistas in the search for causal pathways in cancer induction and progression that will lead to targets for novel intervention strategies. The Cancer Genetic Markers of Susceptibility (CGEMS) initiative (Cancer Bulletin, 2005, Vol 2, Number 16, page 7) will use the latest genomic technologies to perform dense whole genome scans to identify and validate susceptibility genes in the induction and progression of prostate and breast cancer (breast cancer is not the subject of this solicitation). CGEMS represents a three-year NCI enterprise initiative that will be coordinated through the Division of Cancer Epidemiology and Genetics (DCEG), the NCI Core Genotyping Facility (CGF) and the NCI Office of Cancer Genomics (OCG). A major goal of CGEMS will be to make study findings publicly accessible within four months after completion of genotyping through the NCI?s Cancer Biomedical Informatics Grid (caBIG). This access will ensure rapid sharing of results in order to stimulate further analytical and methodological use of the dataset by the extramural scientific community and point to genomic regions which can be followed-up by all investigators. The objective of this solicitation is to seek a qualified vendor to perform a high quality, genome-wide scan of high density Single Nucleotide Polymorphisms (SNPs). The requirement is to assay roughly 300,000 or more distinct SNP genotypes in each of approximately 2500 high quality genomic DNA samples (approximately 750,000,000 genotypes) within 90 days of the contract execution period. This period begins after contract award and specifically when the complete set of NCI samples has been received by the vendor. Fifty percent of the samples are pre-selected prostate cancer cases and other half matched controls. Five Ug of genomic DNA from each sample has already been extracted, quantitated and is currently available for this project. A completion rate of greater than 95% per sample and a per-locus genotype error rate under 0.3% are required. SNP locus selection must follow a specified selection methodology to accomplish the scientific goals of the project.
- Place of Performance
- Address: Contractor Facility
- Record
- SN00920425-W 20051027/051025211656 (fbodaily.com)
- Source
-
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