SOLICITATION NOTICE
A -- National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions - Data Coordinating Center
- Notice Date
- 11/17/2004
- Notice Type
- Solicitation Notice
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-HV-PS-05-09
- Response Due
- 3/3/2005
- Archive Date
- 3/18/2005
- Description
- The National Heart, Lung, and Blood Institute (NHLBI) is soliciting proposals to establish a data coordinating center (DCC) to develop and maintain a registry of patients with Marfan Syndrome and other genetically triggered thoracic aortic aneurysms and cardiovascular complications. The DCC will recruit five (5) regional clinical centers (RCCs) which will collect and transmit to the DCC data, blood and tissue specimens on patients referred for treatment due to Marfan-related or other genetically triggered cardiovascular complications. The DCC will collect and analyze clinical and laboratory data from RCCs on patients receiving treatment for aortic dilatation, aortic insufficiency, heart failure, or aortic valve repair. The registry will provide data about the RCCs and patient-care providers, treatment and patient characteristics, and outcomes in the hospital and in follow-up to researchers both inside and outside the registry who are interested in advancing the fundamental understanding of genetic aortic aneurysms or management of connective tissue disorder afflicted patients. An important capacity of the registry will be to collect family pedigrees and develop screening protocols for extended families. It is estimated that 300 connective tissue disorder patients receive valvular surgery each year and that many more patients are being followed for aortic root disease and heart failure. The expected capacity of the registry for collection of new patient data and specimens is 1,000/year for a period of 4 years. Specifically, the DCC will: a) develop study protocols to collect data, blood and tissue samples, a manual of operations and study forms and informed consent documents in collaboration with a steering committee consisting of a study chair, DCC Principal Investigator, RCC representatives and the NHLBI, b) collect, format and store data, c) provide statistical analysis of the data and develop necessary software for this analysis, d) establish methods and procedures for tissue collection and storage, and e) facilitate interaction among the RCCs and provide administrative and logistical support for publication and dissemination of findings. The Government anticipates that one (1) contract will be awarded on a cost reimbursement, incrementally funded basis, for a period of five (5) years. This acquisition has been designated as full and open competition under the North American Industry Classification System (NAICS) code is 541710 with a business size standard of 500 employees. The solicitation is scheduled for electronic release approximately November 25, 2004. The RFP will be available at the FedBizOpps Website: http://www.fedbizopps.gov and at the NHLBI Website: http://www.nhlbi.nih.gov/funding/inits/index.htm#rfp. IT IS THE OFFERORS RESPONSIBILITY TO MONITOR THE ABOVE INTERNET SITE FOR THE RELEASE OF THE SOLICITATION AND AMENDMENTS, IF ANY. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE SOLICITATION AND AMENDMENTS.
- Record
- SN00709364-W 20041119/041117211757 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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