Loren Data's SAM Daily™

FBO DAILY ISSUE OF SEPTEMBER 15, 2004 FBO #1024
SOLICITATION NOTICE

A -- Animal Models for the Prevention and Treatment of Hepatitis B and Hepatitis C

Notice Date

9/13/2004
 

Notice Type

Solicitation Notice
 

NAICS

541710 — Research and Development in the Physical, Engineering, and Life Sciences
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Program 6700 B Rockledge Room 3214 MSC7612, Bethesda, MD, 20892-7612
 

ZIP Code

20892-7612
 

Solicitation Number

RFP-NIH-NIAID-DMID-05-12
 

Response Due

1/5/2005
 

Archive Date

1/20/2005
 

Description

The purpose of this initiative is to support the National Institute of Allergy and Infectious Diseases (NIAID) in its mission to treat, and prevent the infectious diseases caused by two different hepatitis viruses, hepatitis B (HBV) and hepatitis C (HCV). Chronic infections by either virus affect hundreds of millions of people worldwide and may lead to life-threatening conditions like cirrhosis and cancer. Currently licensed therapies against either virus fall short of being curative, may have adverse side effects, and are further complicated by the development of resistant strains or coinfections with other viruses, such as HIV. New safer and more effective therapies are needed to prevent the end stage liver diseases that cause one million hepatitis-related deaths a year. Appropriate animal models are needed to test them. Animal Models to Evaluate New Therapeutic Candidates for HBV and/or HCV. Small mammalian animal models (e.g.: mice, rats, small primates such as tamarins, tupaias, or marmosets, etc.) of HBV or HCV infection and disease are sought to evaluate new therapeutic candidates (drugs, immunomodulators, therapeutic vaccines, etc.) that may reduce or eliminate viral replication or prevent progression of liver disease. Results from testing a therapeutic in the animal model should predict human responses. Important considerations for selecting a model include the guaranteed provision of ample numbers of animals, and the availability of well-documented tools and assays for analysis of outcomes. As dose requirements are based usually on body weight, lighter is better. Endangered mammals or mammals over five (5) kilograms are excluded. All proposals submitted in response to this RFP must include one or more small animal models capable of evaluating therapeutic candidates against either hepatitis B or hepatitis C. Animal Models to Evaluate Protective Vaccine Candidates for HCV. Small mammalian animal models are also sought to evaluate protective vaccine candidates for HCV. Proposals submitted in response to this RFP for HCV may propose to include one or more small animal models capable of evaluating protective vaccine candidates against HCV in addition to animal models for evaluating HCV therapeutic candidates. The same or different animal models may be proposed for the evaluation of HCV therapeutic candidates and protective vaccine candidates. The long-standing woodchuck animal model will not be supported under this RFP. Work on this animal model will be continued through a separate mechanism concurrent with contracts awarded under this RFP. It is anticipated that two to four cost reimbursement, completion type contracts will be awarded for a period of five (5) years, beginning approximately September 1, 2005. RFP NIH-NIAID-DMID-05-12 will be available electronically on or about September 29, 2004, and may be accessed through the NIAID Contract Management Program (CMP) Home page at http://www.niaid.nih.gov/cgi-shl/cmb/rfps.cfm. Please note that the RFP for this acquisition only includes the work statement, deliverable and reporting requirements, special requirements, the technical evaluation criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range will be asked to provide additional documentation to the Contracting Officer. Responses to this RFP will be due approximately January 5, 2005. Any responsible Offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of contact: Yvette Brown, Contract Specialist at ybrown@niaid.nih.gov, telephone: (301) 451-3686, FAX: (301) 480-4675, you may also contact Paul McFarlane, Contracting Officer, Phone (301) 496-0349, email pm24@nih.gov. See government wide numbered note 26. Collect calls will NOT be accepted.
 

Place of Performance

Address: To Be Determined

Zip Code: TBD

Country: TBD
 

Record

SN00671723-W 20040915/040913212916 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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