SOURCES SOUGHT
A -- Synthesis and Testing of Nonsteroidal and Nonhormonal Male Contraceptive Agents
- Notice Date
- 6/15/2004
- Notice Type
- Sources Sought
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, MD, 20892-7510
- ZIP Code
- 20892-7510
- Solicitation Number
- Reference-Number-NIH-NICHD-11
- Response Due
- 7/15/2004
- Archive Date
- 7/30/2004
- Point of Contact
- Robert Stallings, Contract Specialist, Phone 301-435-6965, Fax 301-402-3676,
- E-Mail Address
-
bs79d@nih.gov
- Description
- Small Business Sources Sought: The Contraception and Reproductive Health Branch, Center for Population Research, and National Institute of Child Health and Human Development is planning to recompete its current contract for the synthesis and testing of nonsteroidal and nonhormonal male contraceptive agents which prevent the formation of spermatozoa in the testis, prevent the maturation of spermatozoa in the epididymis, and alter the integrity of stored spermatozoa. Such compounds should be devoid of (or have minimal) ancillary endocrine, central nervous system, cardiovascular and/or other side effects. The reversibility of infertility after drug treatment is desirable. Safe drugs that result in sterility will be considered. Offerors must have medicinal and/or synthetic organic chemists on staff to carry out the proposed synthetic chemical and testing program. The Federal Government is prepared to test such compounds in several standard assays if the contractor is unable to perform such testing. Specifically excluded from this project are GnRH analogs, gossypol derivatives, steroids, cytotoxic agents including triptolide, tripdiolide and tripchlorolide, and all alkylating agents including expoxy compounds, fluoroacetamide, chloro- and bromohydrin, deoxyhalosugars, nitrogen mustards, ethyleneimines, and sulfonoxylalkanes including ethylene glycol disulfonate. Also excluded are nucleosides, nucleotides, nonspecific antimetabolites, antimitotic agents such as colchicine, N-substituted diamines (i.e., WIN. 13,099), most major classes of antibiotics including the macrolides, penicillins, cephalosporins, quinolones and tetracyclines, sulfasalzazine, cotrimoxazole, and ketoconazole. Nitroheterocyclic compounds are also excluded. Proposals to merely collect compounds from various sources and/or only perform biological assays will not be considered. All responsible sources may submit a proposal which shall be considered by the agency. The required service is defined as code 541710 under the North American Industry Classification System (NAICS). For the purpose of this synopsis, a small business is defined as one that employs no more than 500 persons. Small businesses that believe they have the ability to satisfy the stated requirement, and meet the above size standards, are encouraged to submit a capability statement within 30 days of the publication of this synopsis. Your capability statement should be limited to twenty-five pages or less and include: a description of extensive experience in designing, synthesizing and testing nonsteroidal and nonhormonal male contraceptive agents. THIS ANNOUNCEMENT IS NOT A REQUEST FOR PROPOSALS. If responses indicate the likelihood of satisfactory competition among qualified small businesses, the anticipated solicitation will be restricted to small businesses only. Interested organizations should submit a letter of interest and capability statement, via e-mail, fax, or mail, within 30 days of the date of this publication, to: Robert Stallings, Contract Specialist, Contracts Management Branch, OAM, NICHD, 6100 Executive Boulevard, Suite 7A07, MSC 7510, Bethesda, Maryland, 20892-7510; e-mail-nichdcmb@mail.nih.gov.
- Record
- SN00603468-W 20040617/040615211649 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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