SOURCES SOUGHT
A -- Research project involving serologic assays and associated reagents for detection of immune response to Brucella and Burkholderia spp.
- Notice Date
- 1/28/2003
- Notice Type
- Sources Sought
- Contracting Office
- Department of Health and Human Services, Center for Disease Control and Prevention, Procurement and Grants Office (Atlanta), 2920 Brandywine Road, Room 3000, Atlanta, GA, 30341-4146
- ZIP Code
- 30341-4146
- Solicitation Number
- Reference-Number-SS-002
- Archive Date
- 3/15/2003
- Point of Contact
- Michael Detmer, Supervisory Contract Specialist, Phone (404) 639-0714, Fax (404) 638-5461, - Michael Detmer, Supervisory Contract Specialist, Phone (404) 639-0714, Fax (404) 638-5461,
- E-Mail Address
-
MDetmer@cdc.gov, MDetmer@cdc.gov
- Description
- This is a request for information only. It is not a request for proposal (RFP) and does not commit the Government to issue a solicitation, make an award, or pay any costs associated with responding to this request for information. All submitted information shall remain with the Government and will not be returned. The Centers for Disease Control and Prevention (CDC) has developed standardized and, in some cases, validated serologic, microbiologic and molecular methods for laboratory identification and subtyping of Brucella and Burkholderia spp. (agents causing brucellosis, melioidosis and glanders). A collection of representative isolates were selected from over 1000 available strains to provide temporal, geographical, source and genetic diversity, and were used to validate all methods. Efforts are currently focused on modification and/or development and further validation of serologic methods to detect human immune response to these agents. Presently available methods, such as indirect haemagglutination test (IHA), microscopic agglutination test (MAT) and serum based - ELISAs-, as well as several commercially available screening tests, do not provide diagnostically relevant levels of sensitivity and specificity. Some of the problematic areas in the assays that already exist are the lack of assay standardization, validation, and variations in antigen preparation and quality control, resulting in different levels of purity, and absence of an appropriate and validated standard human reference sera and quality control sera. CDC is seeking partners for a potential collaborative research project that would result in identification of conserved immunogenic antigens that induce immune responses that correlate with protection, and then modification and/or development and validation of sensitive and specific serologic assays based on these antigens. This would include standardization of the assays, standardization of the antigen preparation, development of reference reagents including new national reference sera for the respective assay validations, and finally, transfer of the technology to public health laboratories. A sufficient number of positive and negative sera will be needed so that there will be no ambiguity with determining the sensitivity and specificity of the assays. The CDC goal is to establish and maintain serologic assays and associated reagents for detection of immune response to Brucella and Burkholderia spp., that would be widely available, and effectively utilized in clinical laboratories and State and local Public Health Laboratories. Interested organizations are encouraged to submit information that would be sufficient to assess the organizations ability to pursue research in the above area. Standard capability statements and marketing information is not desired. Submitted information should focus on previous experience and current capabilities in the relevant areas. Only those organizations with a strong background and experience in developing immunologic assays should respond. It is intended that CDC will review the submitted information to assess the possibility of pursuing a collaborative or cooperative research and development agreement. Responses should be prepared in MS Word format, not exceeding ten pages in length. Electronic responses via e-mail can be sent to MMD4@CDC.GOV by 4:00pm eastern time, February 28th, 2003. Questions regarding this request for information can be directed to Michael Detmer at the above e-mail address or by calling 404 639-0714.
- Record
- SN00247800-W 20030130/030128213132 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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