Loren Data's SAM Daily™

FBO DAILY ISSUE OF SEPTEMBER 21, 2002 FBO #0293
SOLICITATION NOTICE

A -- Pharmacokinetics and Pharmacodynamics of Antimicrobials in Animal Model

Notice Date

9/19/2002
 

Notice Type

Solicitation Notice
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Institutes of Allergy and Infectious Diseases, Contract Management Branch 6700 B Rockledge Room 2230 MSC7612, Bethesda, MD, 20892-7605
 

ZIP Code

20892-7605
 

Solicitation Number

RFP-NIH-NIAID-DAIDS-03-21
 

Point of Contact

Paul McFarlane, Senior Contracting Officer, Phone 301-496-0349, Fax 301-402-0972, - Paul McFarlane, Senior Contracting Officer, Phone 301-496-0349, Fax 301-402-0972,
 

E-Mail Address

pm24v@nih.gov, pm24v@nih.gov
 

Description

The purpose of this initiative is to support the National Institute of Allergy and Infectious Diseases (NIAID) in its mission to stimulate research towards discovery of improved therapies for tuberculosis, an important disease of global proportions and an infection associated with the acquired immunodeficiency syndrome (AIDS), an increasing health risk to the world?s population. The rising incidence of tuberculosis, particularly in conjunction with the spread of human immunodeficiency virus (HIV), has contributed to a public health concern. The emergence of multi-drug resistant tuberculosis has produced sizable medical challenges to the treatment and containment of infectious tuberculosis in the face of limited chemotherapeutic options. In order to facilitate the development of improved drugs for the treatment of tuberculosis, and particularly multi-drug resistant tuberculosis, the NIAID requires the directed evaluation of selected novel synthetic and pure natural product compounds as potential tuberculosis antimicrobials. It is envisioned that compounds will be submitted under confidentiality agreements by pharmaceutical houses or research institutions in exchange for microbiological information on the relative potency of compounds against Mycobacterium tuberculosis. The goal of this effort will be to encourage the rapid and efficient exploration of new classes of compounds for development as potential anti-tuberculosis agents. This contract will serve as the central facility for evaluation of novel compounds for physical, pharmacokinetic, and pharmacodynamic properties. Three other existing contracts will provide the laboratory facilities for acquisition, information management, microbiological tuberculosis screening and animal efficacy testing, respectively. The successful contractor will be required to interact and share reagents with these laboratories. Because of the critical public health need to rapidly identify and develop new candidate drugs to combat tuberculosis, the highly technical nature of the work required, and the numerous physiological and microbiological assays producing critical information, close coordination of the Contractor?s efforts by the Project Officer will be necessary. This RFP solicits for an additional contractor to the current drug development program that provides assistance to the Government for the appropriate evaluation of lead compounds in animals. Cooperation and information exchange among all the contractors involved in the drug development program will be paramount to advancing new antimicrobials forward in the development process. It is anticipated that one (1) cost reimbursement, completion type contract will be awarded for a period of seven (7) years, beginning approximately September 30, 2003. RFP NIH-NIAID-DAIDS-03-21 will be available electronically on or about September 30, 2002, and may be accessed through the NIAID Contract Management Branch (CMB) Home page at http://www.niaid.nih.gov/cgi-shl/cmb/rfps.cfm. Please note that the RFP for this acquisition only includes the work statement, deliverable and reporting requirements, special requirements, the technical evaluation criteria, and the proposal preparation instructions. All information required for the submission of an offer will be contained in the electronic RFP package. Following proposal submission and the initial review process, Offerors comprising the competitive range will be asked to provide additional documentation to the Contracting Officer. Responses to this RFP will be due approximately January 21, 2003. Any responsible Offeror may submit a proposal, which will be considered by the Government. This advertisement does not commit the Government to award a contract. Point of contact: Yvette Brown, Contract Specialist at ybrown@niaid.nih.gov, telephone: (301) 496-0612, FAX: (301) 480-5253 you may also contact Paul McFarlane, Contracting Officer, Phone (301) 496-0349, email pm24@nih.gov. No collect calls will be accepted.
 

Place of Performance

Address: To Be Determined

Zip Code: TBD

Country: TBD
 

Record

SN00171039-W 20020921/020919213319 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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