SOLICITATION NOTICE
66 -- 66-NeuroCCD Imaging System
- Notice Date
- 9/5/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-20142-NQ
- Point of Contact
- Cynthia Brown, Purchasing Agent, Phone (301) 496-8608, Fax (301) 402-4513, - Caren Rasmussen, Lead Contract Specialist, Phone (301) 402-4509, Fax (301) 402-4513,
- E-Mail Address
-
cb106x@nih.gov, cr214i@nih.gov
- Small Business Set-Aside
- Total Small Business
- Description
- National Cancer Institute on behalf of the National Institute of Neurological Disorder and Stroke, Laboratory of Neural Control (LNC), proposes to enter into a sole source contract with RedShirtImaging, LLC, 2 Stoneleigh Road, Fairfield, CT 06432, for a NeuroCCD Imaging System. Research in the Cellular and Systems Neurobiology Section (CCN) is devoted to understanding fundamental neurobiological mechanisms generating patterns of neural activity underlying breathing movements in the mammalian central nervous system. The CSN research has important applications not only for advancing the understanding of neuron and neural network function in the mamalian brain, but also understanding neuropathological conditions resulting from disfunction of central nervous system respiratory networks. CNS major objective of this research is to determine the functional and structural properties of respiratory neurons and networks in the brainstem. During the past five years, the CSN has developed imaging techniques that allow the activity of single neurons and populations of neurons to be visualized in real time with videomicroscopic imaging techniques applied to in vitro experimental preparations including brainstem slices isolated from the neonatal rodent nervous system. These techniques have proven to be valuable for reconstructing patterns of activity of the in vitro respiratory network - an important step in understanding network function. The imaging methodology employed utilizes staining of neurons with calcium-sensitive fluorescent dyes that change their fluorescence intensity when neurons become active and thereby emit optical signals that can detected with a photodetector, specifically a CCDcamera, in a video format for real-time visualization of neuronal calcium activity. The CSN plans to utilize voltage-sensitive dyes that like the calcium dyes allow neuron and neuron population imaging in real time, but provide a much higher temporal resolution (msec resolution), thus overcoming limitations of the calcium dyes and associated imaging system. In order for the CNS to utilize the voltage-sensitive dyes a new imaging system is required that has been optimzed for detection of the faster signals emitted by the voltage-sensitive dyes, which have fundamentally differenet systems requirements than the current system being utilzied for detection of calcium dye signals. Specific requirements are: 1)low noise, cooled CCD camera for low signal detection; 2) optical signal transfer from the CD camera chip at rate substantially higher (up to 50 Hz) than ordinary video rate to achieve higher temporal resolution; 3) CCD camera system has appropriate spatial resolution for imaging populations of neurons that may be spatially distributed; 4) capability for control over the number of camera pixels utilized for optical data accumulation (advanced software system for automatic control of pixel number); 5) data transfer from the CCD camera can be gated by computer control of the camera (requiring advanced software); 6) system must be uniquely designed for the detection of optical signals from voltage-sensitive dyes. Redshirtimaging LLC, is the only source known to the Government that can provide the above item with the required features. However, if any interested party believes it can meet the above requirements, it may submit a statement of capabilities. The capability statement and any other furnished information must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can fully meet the Government's requirements herein. Capability statements must be received in the contracting office no later than 1:30 PM EDT on September 12, 2002. This action is pursuant to 41 USC 253(1) and under the authority of FAR 6.302-1. This requirement will be procured as a commercial item in accordance with FAR Part 12. If you have any questions, please contact Cynthia Brown, Purchasing Agent, (301) 402-4509. A determination by the Government not to compete this proposed requirement based on responses to this notice is solely within the discretion of the Government. Information received shall be considered solely for the purpose of determining whether to conduct a competitive procurement. The NAICS Code: 334513 and the business size standard is 500 employees. No collect calls will be accepted.
- Record
- SN00158343-W 20020907/020905213314 (fbodaily.com)
- Source
-
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